87181-38-2Relevant academic research and scientific papers
acetic Acid Esters. A New Class of High-Ceiling Diuretics. 2. Modifications of the Oxyacetic Side Chain
Plattner, Jacob J.,Fung, Anthony K.L.,Smital, Jill R.,Lee, Cheuk-Man,Crowley, Steven R.,et al.
, p. 1587 - 1596 (2007/10/02)
The discovery of high-ceiling natriuretic activity from a series of aminomethyl derivatives of ethyl acetate prompted our continued investigation of this new class of (aryloxy)acetic acid diuretics.Systematic alte
Diphenyl ether, diphenyl thioether and diphenyl methane phenol mannich bases
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, (2008/06/13)
Described are compounds of the formula STR1 wherein R is hydrogen, loweralkyl, aminomethyl or halo; R1 is carboxy, carboxyloweralkyl, aminocarbonyl, hydroxymethyl, anilinomethyl, or aminomethyl; A is oxygen, CH2, Sulfur or a single bond; X is oxygen, CH2, sulfur or sulfoxide; and Y is hydrogen, loweralkyl or halo and may be the same or different, and pharmaceutically acceptable salts thereof. The compounds are effective as diuretic agents.
