87188-50-9

Basic information

• Product Name: TERT-BUTYL 4-FORMYLPHENYL CARBONATE
• Synonyms: TERT-BUTYL 4-FORMYLPHENYL CARBONATE;tert-Butyl 4-formylphenyl carbonate 97%
• CAS NO: 87188-50-9
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Product Categories: Carbonates;Carbonyl Compounds;Organic Building Blocks
• Mol File: 87188-50-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 71-74 °C(lit.)
• Boiling Point: 328.4°C at 760 mmHg
• Flash Point: 143.6°C
• Appearance: /
• Density: 1.141g/cm³
• Vapor Pressure: 0.00019mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: TERT-BUTYL 4-FORMYLPHENYL CARBONATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 4-FORMYLPHENYL CARBONATE(87188-50-9)
• EPA Substance Registry System: TERT-BUTYL 4-FORMYLPHENYL CARBONATE(87188-50-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 87188-50-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O4/c1-12(2,3)16-11(14)15-10-6-4-9(8-13)5-7-10/h4-8H,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 123-08-0 4-hydroxy-benzaldehyde 
• 149925-10-0 C₁₄H₂₀O₅ 
• 1291099-39-2 C₁₃H₁₇NO₆ 
• 1291099-42-7 C₁₃H₁₉NO₄ 
• 1291099-43-8 C₁₆H₂₅NO₄ 
• 1291099-44-9 (R)-N-isopropylnorsynephrine hydrochloride 
• 1316276-90-0 C₁₉H₂₀O₅ 
• 156281-11-7 tert-butyl (4-(hydroxymethyl)phenyl)carbonate 
• 390815-79-9 tert-butyl (4-(chloromethyl)phenyl)carbonate 
• 1058720-73-2 4-(2-(4,5-dihydro-1,3-thiazol-2-ylamino)-2-pyridin-3-ylethyl)-phenol 
• 1058720-94-7 4-(2-amino-2-pyridin-3-yl-ethyl)phenol 

Relevant articles and documents

PhIO-Mediated oxidative dethioacetalization/dethioketalization under water-free conditions

Treatment of thioacetals and thioketals with iodosobenzene in anhydrous DCM conveniently afforded the corresponding carbonyl compounds in high yields under water-free conditions. The mechanistic studies indicate that this dethioacetalization/dethioketalization process does not need water and the oxygen of the carbonyl products comes from the hypervalent iodine reagent.

Cellular protection of SNAP-25 against botulinum neurotoxin/A: Inhibition of thioredoxin reductase through a suicide substrate mechanism

Botulium neurotoxins (BoNTs) are among the most lethal toxins known to man. They are comprised of seven serotypes with BoNT/A being the most deadly; yet, there is no approved therapeutic for their intoxication or one that has even advanced to clinical trials. Botulinum neurotoxicity is ultimately governed through light chain (LC) protease SNARE protein cleavage leading to a loss of neurotransmitter release. Pharmacological attempts to ablate BoNT/A intoxication have sought to either nullify cellular toxin entry or critical biochemical junctions found within its intricate mechanism of action. In these regards, reports have surfaced of nonpeptidic small molecule inhibitors, but few have demonstrated efficacy in neutralizing cellular toxicity, a key prerequisite before rodent lethality studies can be initiated. On the basis of a lead discovered in our BoNT/A cellular assay campaign, we investigated a family of N-hydroxysuccinimide inhibitors grounded upon structure activity relationship (SAR) fundamentals. Molecules stemming from this SAR exercise were theorized to be protease inhibitors. However, this proposition was overturned on the basis of extensive kinetic analysis. Unexpectedly, inhibitor data pointed to thioredoxin reductase (TrxR), an essential component required for BoNT protease translocation. Also unforeseen was the inhibitors' mechanism of action against TrxR, which was found to be brokered through a suicide-mechanism utilizing quinone methide as the inactivating element. This new series of TrxR inhibitors provides an alternative means to negate the etiological agent responsible for BoNT intoxication, the LC protease.

MgBr 2 · OEt 2: A Lewis Acid Catalyst for the O - And N -Boc Protection of Phenols and Amines

MgBr2 · OEt2 efficiently catalyzes the O- and N-tert-butoxycarbonylation of functionalized phenols and amines. The presented procedure is operationally simple and done under solvent-free conditions. GRAPHICAL ABSTRACT.