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best quality Good Supplier 872-50-4 N-methyl prrolidone(NMP) on hot selling
Cas No: 872-50-4
No Data 1 Metric Ton 1 Metric Ton/Day Dongying H&Y Chemical Co., Ltd. Contact Supplier
Best Price 1-methyl-2-pyrrolidinone
Cas No: 872-50-4
USD $ 1.8-4.0 / Kilogram 1 Kilogram 2000 Metric Ton/Year Xiamen BaiFuchem Co.,Ltd Contact Supplier
Electronic Grade 99.9% Purity Liquid NMP 1-Methyl-2-pyrrolidone
Cas No: 872-50-4
USD $ 6.5-6.5 / Metric Ton 1 Metric Ton 36 Metric Ton/Week Hangzhou Johoo Chemical Co., Ltd Contact Supplier
High quality n-methyl-2-pyrrolidinone supplier in China
Cas No: 872-50-4
No Data 1 Kilogram 2000 Metric Ton/Day Simagchem Corporation Contact Supplier
N-Methyl-2-pyrrolidone
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No Data 1 Kilogram 3000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
Good quality N-Methyl-2-pyrrolidone,NMP for hot sale
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USD $ 1.0-2.0 / Kilogram 1 Kilogram 200 Metric Ton/Day Wuxi TAA Chemical Industry Co.,LTD. Contact Supplier
Wholesale Price 99% Purity 1-Methyl-2-Pyrrolidinone CAS 872-50-4
Cas No: 872-50-4
USD $ 10.0-10.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Hebei Qianglong Technology import and export Co, LTD Contact Supplier
1-Methyl-2-pyrrolidinone 872-50-4
Cas No: 872-50-4
No Data No Data Metric Ton/Day Luyunjia Chemistry Xiamen Limited Contact Supplier
Supply high quality N-methyl-pyrrolidinone
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No Data 1 Kilogram 20000 Metric Ton/Year Aecochem Corp. Contact Supplier
Lower factory price 1-Methyl-2-pyrrolidinone (NMP) Cas 872-50-4 with best purity
Cas No: 872-50-4
USD $ 65.0-65.0 / Kilogram 1 Kilogram 40 Metric Ton/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier

872-50-4 Usage

Uses

Solvent for high-temperature resins; petrochemical processing, in the microelectronics fabrication industry, dyes and pigments, industrial and domestic cleaning compounds; agricultural and pharmaceutical formulations

toxicity

Oral (mus)LD50:5130 mg/kg;Oral (rat)LD50:3914 mg/kg;Dermal (rbt)LD50:8000 mg/kg.

Synthesis Reference(s)

Tetrahedron Letters, 24, p. 1323, 1983 DOI: 10.1016/S0040-4039(00)81646-9

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in fire.

Industrial uses

1) 1-Methyl-2-pyrrolidinone is used as a general dipolar aprotic solvent, stable and unreactive; 2) for extraction of aromatic hydrocarbons from lubricating oils; 3) for carbon dioxide removal in ammonia generators; 4) as a solvent for polymerization reactions and polymers; 5) as a paint stripper; 6) for pesticide formulations (USEPA 1985). Other non-industrial uses of 1-Methyl-2-pyrrolidinone are based on its properties as a dissociating solvent suitable for electrochemical and physical chemical studies (Langan and Salman 1987). Pharmaceutical applications make use of the properties of 1-Methyl-2-pyrrolidinone as a penetration enhancer for a more rapid transfer of substances through the skin (Kydoniieus 1987; Barry and Bennett 1987; Akhter and Barry 1987). 1-Methyl-2-pyrrolidinone has been approved as a solvent for slimicide application to food packaging materials (USDA 1986).

Definition

ChEBI: A member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.

Reactivity Profile

This amine is a very mild chemical base. 1-Methyl-2-pyrrolidinone does tend to neutralize acids to form salts plus water. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Contact allergens

1-Methylpyrrolidone is an aprotic solvent with a wide range of applications: petrochemical processing, surface coating, dyes and pigments, industrial and domestic cleaning compounds, and agricultural and pharmaceutical formulations. It is mainly an irritant, but it can cause severe contact dermatitis due to prolonged contact.

Metabolism

Male Sprague-Dawley rats were given a single intraperitoneal injection (45 mg/kg) of radiolabeled 1 -methyl-2-pyrrolidone. Plasma levels of radioactivity and compound were monitored for six hours and the results suggested a rapid distribution phase which was followed by a slow elimination phase. The major amount of label was excreted in the urine within 12 hours and accounted for approximately 75% of the labelled dose. Twenty-four hours after dosage, cumulative excretion (urine) was approximately 80% of the dose. Both ring- and methyl-labeled species were used, as well as both [14C]- and [3H]-labeled l-methyl-2-pyrrolidone. The initial labeled ratios were maintained during the first 6 hours after dosage. After 6 hours, the liver and intestines were found to contain the highest accumulations of radioactivity, approximately 2-4% of the dose. Little radioactivity was noted in the bile or respired air. High performance liquid chromatography of urine showed the presence of one major and two minor metabolites. The major metabolite (70-75% of the administered radioactive dose) was analyzed by liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry and was proposed to be a 3- or 5-hydroxy-l-methyl-2-pyrrolidone (Wells 1987).

Chemical Properties

1-Methyl-2-pyrrolidinone is a colourless or light yellow liquid with an amine odour. It can undergo a number of chemical reactions even though it is accepted as a stable solvent. It is resistant to hydrolysis under neutral conditions, but strong acid or base treatment results in ring opening to 4-methyl aminobutyric acid. 1-Methyl-2-pyrrolidinone can be reduced to 1-methyl pyrrolidine with borohydride. Treatment with chlorinating agents results in amide formation,an intermediate which can undergo further substitution, while treatment with amyl nitrate yields the nitrate. Olefins can be added to the 3 position by treatment first with oxalic esters, then with appropriate aldehyes (Hort and Anderson 1982).

General Description

N-Methyl-2-Pyrrolidone (NMP) is a powerful, aprotic solvent with high solvency, and low volatility. This colorless, high boiling, high flash point and low vapor pressure liquid carries a mild amine-like odor. NMP has high chemical and thermal stability and is completely miscible with water at all temperatures. NMP can serve as a co-solvent with water, alcohols, glycol ethers, ketones, and aromatic/chlorinated hydrocarbons. NMP is both recyclable by distillation and readily biodegradable. NMP is not found on the Hazardous Air Pollutants (HAPs) list of the 1990 Clean Air Act Amendments.

Uses

1-Methyl-2-pyrrolidone is a polar solvent that is used in organic chemistry and polymer chemistry. Large scale applications include the recovery and purification of acetylenes, olefins, and diolefins, gas purification, and aromatics extraction from feedstocks. 1-Methyl-2-pyrrolidinone is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.

Uses

1-Methyl-2-pyrrolidinone (NMP) is a polar aprotic solvent that has the advantages of low toxicity, high boiling point, outstanding solvency, strong selectivity and good stability. It is widely used in purification of aromatic hydrocarbon extraction, acetylene, olefins, and diolefins. It is used in industrial cleaning, and it serves as a solvent for production of pesticides, engineering plastics, coatings, synthetic fibers, and integrated circuits. It can also be used as an industrial cleanser, dispersant, dye, lubricant and antifreeze. 1-Methyl-2-pyrrolidinone is an excellent solvent, widely used in aromatics extraction, lubricating oil refining, acetylene enrichment, butadiene separation and synthesis gas desulfurization. It is used in gas desulfurization, lubricating oil refining, lubricating oil antifreeze, olefin extraction, and as a solvent for insoluble engineering plastics polymerization. It can be used in herbicide, to clean insulation materials, semiconductor industry precision instruments and circuit boards, to recycle PVC exhaust, as a detergent, dye supplement and dispersing agent. It is used in mediums for polymerization reactions such as engineering plastics and aramid fiber. 1-Methyl-2-pyrrolidinone is used as a polyvinylidene fluoride solvent and electrode auxiliary material for lithium ion batteries. high purity grade for ICP-MS detection. For peptide synthesis.

Health Hazard

Inhalation of hot vapors can irritate nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Repeated and prolonged skin contact produces a mild, transient irritation.

Metabolic pathway

Rats are administered radio-labeled N-methyl-2- pyrrolidinone (NMP), and the major route of excretion by rats is via the urine. The major metabolite, representing 70-75% of the administered dose, is 4-(methylamino)butenoic acid. This unsaturated intact product may be formed from the elimination of water, and a hydroxyl group may be present on the metabolite prior to acid hydrolysis.

Production Methods

1-Methyl-2-pyrrolidinone is manufactured by the reaction of buytrolactone with methylamine (Hawley 1977). Other processes include preparation by hydrogenation of solutions of maleic or succinic acids with methylamine (Hort and Anderson 1982). Manufacturers of this chemical include Lachat Chemical, Inc, Mequon, Wisconsin and GAF Corporation, Covert City, California.

Hazard

Severe skin and eye irritant. Explosive lim-its 2.2–12.2%.

Description

N-Methyl-2-pyrrolidone is an aprotic solvent with a wide range of applications: petrochemical processing, surface coating, dyes and pigments, industrial and domestic cleaning compounds, and agricultural and pharmaceutical formulations. It is mainly an irritant, but has also caused several cases of contact dermatitis in a small electrotechnical company.

storage

NMP is hygroscopic (picks up moisture) but stable under normal conditions. It will violently react with strong oxidizers such as hydrogen peroxide, nitric acid, sulfuric acid, etc. The primary decomposition products produce carbon monoxide and nitrogen oxide fumes. Excessive exposure or spillage should be avoided as a matter of good practice. Lyondell Chemical Company recommends wearing butyl gloves when using NMP. NMP should be stored in clean, phenolic-lined mild steel or alloy drums. Teflon?1 and Kalrez?1 have been shown to be suitable gasket materials. Please review MSDS prior to handling.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Combustible when exposed to heat, open flame, or powerful oxidizers. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.

Air & Water Reactions

Soluble in water.

Purification Methods

Dry the pyrrolidone by removing water as the *benzene azeotrope. Fractionally distil at 10 torr through a 100-cm column packed with glass helices. [Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] The hydrochloride has m 86-88o (from EtOH or Me2CO/EtOH) [Reppe et al. Justus Liebigs Ann Chem 596 1 1955]. [Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.]

Carcinogenicity

Rats were exposed to NMP vapor at 0, 0.04, or 0.4 mg/L for 6 h/day, 5 days/week for 2 years.Male rats at 0.4 mg/L showed slightly reduced mean body weight. No life-shortening toxic or carcinogenic effects were observed in rats exposed for 2 years to either 0.04 or 0.4mg/L of NMP. By the dermal route, a group of 32 mice received an initiation dose of 25mg of NMP followed 2 weeks later by applications of the tumor promoter phorbol myristate acetate, three times a week, for more than 25 weeks. Dimethylcarbamoyl chloride and dimethylbenzanthracene served as positive controls. Although the NMP group had three skin tumors, this response was not considered significant when compared with that of the positive controls.

Chemical Properties

1-Methyl-2-pyrrolidinone is also known as NMP, 1-methyl-2-pyrrolidone, N-methylpyrrolidone, and N-Methyl-2-pyrrolidone. NMP is a colorless to light yellow transparent liquid with a slight ammonia odor. NMP is completely miscible with water. It is highly soluble in lower alcohols, lower ketones, ether, ethyl acetate, chloroform, and benzene and moderately soluble in aliphatic hydrocarbons. NMP is strongly hygroscopic, chemically stable, not corrosive towards carbon steel and aluminum, and slightly corrosive to copper. It has low adhesiveness, strong chemical and thermal stability, high polarity, and low volatility. This product is slightly toxic, and its permitted concentration limit in air is 100ppm. N-Methylpyrrolidone (NMP) is a solvent used in a variety of industries and applications, such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrial/domestic cleaning.

Waste Disposal

Consult state, local or national regulations for proper disposal. Disposal must be made according to official regulations. Water, if necessary with cleansing agents.
InChI:InChI=1/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

872-50-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (M0418)  1-Methyl-2-pyrrolidone  >99.0%(GC) 872-50-4 25mL 80.00CNY Detail
TCI America (M0418)  1-Methyl-2-pyrrolidone  >99.0%(GC) 872-50-4 100mL 98.00CNY Detail
TCI America (M0418)  1-Methyl-2-pyrrolidone  >99.0%(GC) 872-50-4 500mL 255.00CNY Detail
Alfa Aesar (43894)  1-Methyl-2-pyrrolidinone, ACS grade, 99.0+%    872-50-4 500ml 308.0CNY Detail
Alfa Aesar (43894)  1-Methyl-2-pyrrolidinone, ACS grade, 99.0+%    872-50-4 1L 551.0CNY Detail
Alfa Aesar (43894)  1-Methyl-2-pyrrolidinone, ACS grade, 99.0+%    872-50-4 4L 1616.0CNY Detail
Alfa Aesar (43894)  1-Methyl-2-pyrrolidinone, ACS grade, 99.0+%    872-50-4 *4x1L 1763.0CNY Detail
Alfa Aesar (43894)  1-Methyl-2-pyrrolidinone, ACS grade, 99.0+%    872-50-4 *4x4L 5075.0CNY Detail
Alfa Aesar (38986)  1-Methyl-2-pyrrolidinone, HPLC Grade, 99.5%    872-50-4 1L 834.0CNY Detail
Alfa Aesar (38986)  1-Methyl-2-pyrrolidinone, HPLC Grade, 99.5%    872-50-4 4L 2431.0CNY Detail
Alfa Aesar (38986)  1-Methyl-2-pyrrolidinone, HPLC Grade, 99.5%    872-50-4 *4x1L 2890.0CNY Detail
Alfa Aesar (44063)  1-Methyl-2-pyrrolidinone, Biograde, 99.5%    872-50-4 1L 413.0CNY Detail

872-50-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methylpyrrolidin-2-one

1.2 Other means of identification

Product number -
Other names N-methyl-pyrrolidin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Adhesives and sealant chemicals,Intermediates,Paint additives and coating additives not described by other categories,Plating agents and surface treating agents,Processing aids, not otherwise listed,Processing aids, specific to petroleum production,Solvents (for cleaning or degreasing),Solvents (which become part of product formulation or mixture)
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:872-50-4 SDS

872-50-4Synthetic route

4-butanolide
96-48-0

4-butanolide

methylamine

methylamine

Conditions
ConditionsYield
With water; ZSM-5 at 280℃;99%
In water at 300℃; under 75007.5 Torr; Concentration;99.9%
at 255℃; under 15001.5 Torr; for 3h;98.2%
3-bromo-1-methyl-pyrrolidin-2-one
33693-57-1

3-bromo-1-methyl-pyrrolidin-2-one

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With indium; water at 20℃; for 6h;99%
1-Methylpyrrolidine
120-94-5

1-Methylpyrrolidine

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With 5.4 wt% Au/CeO2; water; oxygen In 1,4-dioxane at 80℃; under 760.051 Torr; for 3.5h; Catalytic behavior; Reagent/catalyst; Temperature; Concentration; Schlenk technique;97%
With iodosylbenzene In water for 36h;55%
With tert.-butylhydroperoxide; [Mn(GBOA)2(H2O)2]*(Cl)2*4H2O In acetonitrile at 50 - 55℃;49.4%
With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); water; sodium hydroxide at 160℃; for 48h; Inert atmosphere; Schlenk technique;22%
With water; oxygen at 80℃; under 760.051 Torr; for 24h; Green chemistry; regioselective reaction;> 99 %Chromat.
cyclobutanone
1191-95-3

cyclobutanone

N-Methyl-O-p-nitrophenylsulphonylhydroxylamine
85462-16-4

N-Methyl-O-p-nitrophenylsulphonylhydroxylamine

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
In chloroform 1.) -78 deg C, 2.) 25 deg C;96%
In chloroform at 25℃;96%
In chloroform at 25℃; other ketones, also with ketals, other reagent, other solvent;96%
4-butanolide
96-48-0

4-butanolide

dimethyl amine
124-40-3

dimethyl amine

methylamine
74-89-5

methylamine

trimethylamine
75-50-3

trimethylamine

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
at 255℃; for 3h;94.8%
2-pyrrolidinon
616-45-5

2-pyrrolidinon

carbon dioxide
124-38-9

carbon dioxide

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With copper nanoparticles-decorated triazinetriamine derived porous organic polymer; polymethylhydrosiloxane In acetonitrile at 80℃; under 760.051 Torr; for 8h; Inert atmosphere;94%
1-(dimethylchlorosilylmethyl)-2-pyrrolidone
76128-61-5

1-(dimethylchlorosilylmethyl)-2-pyrrolidone

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

diisopropoxydimethylsilane

diisopropoxydimethylsilane

Conditions
ConditionsYield
With sodium isopropylate In isopropyl alcohol at 60℃; for 3h;A 92%
B 92%
1-Methyl-2,2-dipropoxy-pyrrolidine

1-Methyl-2,2-dipropoxy-pyrrolidine

2-Benzyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole
79108-52-4

2-Benzyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

2-Benzyl-7-propyl-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole

2-Benzyl-7-propyl-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 90%
1-Methyl-2,2-dipropoxy-pyrrolidine
79108-53-5

1-Methyl-2,2-dipropoxy-pyrrolidine

Biriperone
42021-34-1

Biriperone

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

1-(4-Fluoro-phenyl)-4-(7-propyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-butan-1-one
79108-61-5

1-(4-Fluoro-phenyl)-4-(7-propyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-butan-1-one

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 90%
Biriperone
42021-34-1

Biriperone

2,2-dimethoxy-1-methylpyrrolidine
39650-82-3

2,2-dimethoxy-1-methylpyrrolidine

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

1-(4-Fluoro-phenyl)-4-(7-methyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-butan-1-one
79108-56-8

1-(4-Fluoro-phenyl)-4-(7-methyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-butan-1-one

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 90%
4-(methylamino)butyric acid
1119-48-8

4-(methylamino)butyric acid

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With titanium tetrakis(trimethylsilanolate) at 120℃; for 1h; Reagent/catalyst; Temperature; Solvent; Ionic liquid; Inert atmosphere;88%
With titanium(IV) isopropylate In 1,2-dichloro-ethane for 5h; Heating;85%
2-Benzyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole
79108-52-4

2-Benzyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

2,2-dimethoxy-1-methylpyrrolidine
39650-82-3

2,2-dimethoxy-1-methylpyrrolidine

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

2-Benzyl-7-methyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole
79108-54-6

2-Benzyl-7-methyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 88%
4-butanolide
96-48-0

4-butanolide

dimethyl amine
124-40-3

dimethyl amine

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

methanol
67-56-1

methanol

Conditions
ConditionsYield
With water; ZSM-5 at 280℃;A 88%
B 10%
Y-type zeoliteA 51%
B 6.6%
2-pyrrolidinon
616-45-5

2-pyrrolidinon

bis(1-methyl-1-phenylethyl)peroxide
80-43-3

bis(1-methyl-1-phenylethyl)peroxide

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With copper(l) chloride In chlorobenzene at 130℃; for 12h; Schlenk technique; Inert atmosphere;87%
N-methyl-2-pyrrolidone oxime
35197-40-1

N-methyl-2-pyrrolidone oxime

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With selenium(IV) oxide In toluene Heating;86%
N-Methyl-2,2-diethoxypyrrolidine
826-41-5

N-Methyl-2,2-diethoxypyrrolidine

Biriperone
42021-34-1

Biriperone

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

4-(7-Ethyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-1-(4-fluoro-phenyl)-butan-1-one
79108-59-1

4-(7-Ethyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-1-(4-fluoro-phenyl)-butan-1-one

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 85%
maleic acid
110-16-7

maleic acid

methylamine
74-89-5

methylamine

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With hydrogen; ruthenium (III) acetylacetonate; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In water at 250℃; under 31029.7 - 51716.2 Torr; Product distribution / selectivity;83.5%
4-Chloro-N-[2-(3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-benzamide
72593-14-7

4-Chloro-N-[2-(3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-benzamide

2,2-dimethoxy-1-methylpyrrolidine
39650-82-3

2,2-dimethoxy-1-methylpyrrolidine

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

4-Chloro-N-[2-(7-methyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-benzamide
79108-57-9

4-Chloro-N-[2-(7-methyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-benzamide

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 83%
1-(chloromethyl)pyrrolidin-2-one
31282-95-8

1-(chloromethyl)pyrrolidin-2-one

dimethylmonochlorosilane
1066-35-9

dimethylmonochlorosilane

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate for 10h; Heating;82%
With trimethylsilyl trifluoromethanesulfonate for 10h; Heating; other substrates, other reagents;82%
4-methyl-4H-benzo[1,4]oxazin-3-thione
21744-74-1

4-methyl-4H-benzo[1,4]oxazin-3-thione

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With manganese(IV) oxide In chloroform for 12h; Ambient temperature;82%
1-methyl-pyrrolidine-2-thione
10441-57-3

1-methyl-pyrrolidine-2-thione

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0℃; for 2h;82%
With tetrabutylammonium periodite In dichloromethane at 20℃; for 2h;81%
With hydrogenchloride; N-methyl-N-nitrosoaniline; potassium iodide In dichloromethane; water at 22℃; for 2.5h;72%
N-Methyl-2,2-diethoxypyrrolidine
826-41-5

N-Methyl-2,2-diethoxypyrrolidine

4-Chloro-N-[2-(3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-benzamide
72593-14-7

4-Chloro-N-[2-(3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-benzamide

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

4-Chloro-N-[2-(7-ethyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-benzamide
79108-60-4

4-Chloro-N-[2-(7-ethyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-ethyl]-benzamide

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 80%
N-Methyl-2,2-diethoxypyrrolidine
826-41-5

N-Methyl-2,2-diethoxypyrrolidine

2-Benzyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole
79108-52-4

2-Benzyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

2-Benzyl-7-ethyl-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole
79108-58-0

2-Benzyl-7-ethyl-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 79%
4-butanolide
96-48-0

4-butanolide

trimethylamine
75-50-3

trimethylamine

A

1-methyl-pyrrolidin-2-one

1-methyl-pyrrolidin-2-one

B

Conditions
ConditionsYield
ZSM-5A 79%
B 8%
1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With tetraethylammonium bromide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In acetonitrile at 20 - 60℃;78%
1-<(trimethylsilyl)methyl>-2-pyrrolidinone
76596-19-5

1-<(trimethylsilyl)methyl>-2-pyrrolidinone

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With acrylic acid methyl ester In acetonitrile for 17h; Irradiation; Inert atmosphere;77%
C5H10NO2(1-)*K(1+)

C5H10NO2(1-)*K(1+)

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; bis(trichloromethyl) carbonate; potassium hydroxide In water; acetonitrile at 60℃; for 0.00277778h; Inert atmosphere;76%
butane-1-sulfonic acid methyl ester
2374-69-8

butane-1-sulfonic acid methyl ester

N-trimethylsilyl-pyrrolidin-2-one
14468-90-7

N-trimethylsilyl-pyrrolidin-2-one

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

Trimethylsilyl-1-butansulfonat
72500-12-0

Trimethylsilyl-1-butansulfonat

Conditions
ConditionsYield
Heating;A 72%
B 75%
1-Methyl-2,2-dipropoxy-pyrrolidine
79108-53-5

1-Methyl-2,2-dipropoxy-pyrrolidine

2-(2-Pyridin-4-yl-ethyl)-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole
55344-34-8

2-(2-Pyridin-4-yl-ethyl)-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole

A

1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

B

7-Propyl-2-(2-pyridin-4-yl-ethyl)-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole
79123-19-6

7-Propyl-2-(2-pyridin-4-yl-ethyl)-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole

Conditions
ConditionsYield
In tetrahydrofuran at 35℃; for 6h;A n/a
B 74%
1-methyl-pyrrolidin-2-one
872-50-4

1-methyl-pyrrolidin-2-one

Conditions
ConditionsYield
With 2,6-dichloropyridine N-oxide; dichloro(5,10,15,20-tetramesitylporphyrinato)ruthenium(IV) In benzene at 40℃;91%
With pyridine; N-hydroxyphthalimide; sodium perchlorate In acetonitrile controlled potential electrolysis, electrodes: glassy-carbon vs. SCE;81%
With silver tetrafluoroborate; water; Selectfluor In acetone at 40℃; for 1h; Schlenk technique; Inert atmosphere;81%
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