872-81-1Relevant articles and documents
Method for synthesizing 2-propionyl-1-pyrroline
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Paragraph 0017; 0019, (2019/04/26)
The invention belongs to the technical field of chemical synthesis, in particular to a method for synthesizing 2-propionyl-1-pyrroline, comprising the steps of: 1) dissolving pyrrolidine-2-one in dichloromethane, adding dimethylaminopyridine and triethylamine, adding di-tert-butyl dicarbonate under stirring, and after the reaction is finished, conducting washing with distilled water and saturatedbrine; 2) dissolving the intermediate product obtained in the above step in tetrahydrofuran, dropwise adding tetramethylethylenediamine and a Grignard reagent in a low temperature environment to obtain N-boc-4-oxo-aminoheptane; 3) reacting the N-boc-4-oxo-aminoheptane with trifluoroacetic acid to remove the Boc group to obtain propylpyrroline; and 4) conducting specific oxidation on the propylpyrroline by selenium dioxide to obtain a final product 2-propionyl-1-pyrroline. The method has the advantages of simple operation, low cost, low energy consumption, high yield, high product purity and the like, and is more suitable for industrial production.
CYCLIC β-ENAMINOESTERS DECARBOXYLATION WITH BORIC ACID : A CONVENIENT SYNTHESIS OF CYCLIC IMINES
Bacos, Daniel,Celerier, Jean-Pierre,Lhommet, Gerard
, p. 2353 - 2354 (2007/10/02)
Δ1-pyrrolines, Δ1-piperideines and 1-aza 1-cycloheptenes are formed in good yields from the decarboxylation of alkylated cyclic β-enaminoesters with boric acid.