872001-52-0Relevant academic research and scientific papers
Exploration of a new series of CCR5 antagonists: Multi-dimensional optimization of a sub-series containing N-substituted pyrazoles
Lemoine, Remy C.,Petersen, Ann C.,Setti, Lina,Jekle, Andreas,Heilek, Gabrielle,Derosier, Andre,Ji, Changhua,Berry, Pamela,Rotstein, David M.
scheme or table, p. 4753 - 4756 (2010/10/02)
The introduction of N-substituted pyrazoles in a new series of CCR5 antagonists was shown to substantially increase antiviral activity.
HETEROCYCLIC ANTIVIRAL COMPOUNDS
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Page/Page column 137-138, (2010/02/15)
Chemokine receptor antagonists, in particular, 3,7-diazabicyclo [3.3.0] octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are allieviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula (I).
