872018-40-1

Usage

Uses

Used in Pharmaceutical Synthesis:
6-Bromo-3-methylisoquinolin-1(2H)-one is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological and pharmaceutical applications. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 6-Bromo-3-methylisoquinolin-1(2H)-one is used as a starting material for the production of different chemical compounds. Its bromine atom makes it particularly useful for various chemical reactions and transformations, facilitating the creation of novel organic compounds with diverse applications.
Used in Research and Development:
6-Bromo-3-methylisoquinolin-1(2H)-one is utilized in research and development for its potential to contribute to the discovery of new chemical entities and the advancement of organic chemistry. Its unique properties make it an interesting subject for scientific exploration and innovation.

Upstream product

• 872018-47-8 C₁₀H₈BrN₃O 

Relevant academic research and scientific papers

BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Disclosed are a benzazepine derivative, a preparation method, a pharmaceutical composition and the use thereof. A compound as shown in formula (I) of the present invention, and an isomer, a prodrug, a stable isotope derivative or a pharmaceutically acceptable salt thereof have the following structure. The benzazepine derivative of the present invention has a good regulation effect on the TLR family and the related signalling pathway, and in particular, has a good regulation effect on TLR8, can effectively treat, relieve and/or prevent various diseases mediated by TLR family and the TLR-related signalling pathway, and in particular, can effectively treat, relieve and/or prevent various diseases mediated by TLR8, such as cancers, autoimmune diseases, infections, inflammations, transplantation rejections, graft-versus-host diseases, etc.

NEW COMPOUNDS AND THEIR USES 707

The present invention relates to isoquinolinone derivatives of formula (I): should be wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS

The present invention provides a method for treating a thrombotic or an inflammatory disorder administering to a patient in need thereof a therapeutically effective amount of at least one compound of Formula (I) or Formula (V): (I) [INSERTCHEMICAL STRUCTURE HERE] (V)[INSERT CHEMICAL STRUCTURE HERE] or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, R4, R6, R11, X1, X2, and X3 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also provides compounds within the scope of Formula I and relates to pharmaceutical compositions comprising these compounds.