87202-26-4Relevant academic research and scientific papers
AUXILIARY SILICON IN REGIOSELECTIVE COBALT CATALIZED PROTOBERBERINE SYNTHESES
Hillard, Russel L.,Parnell, Carol A.,Vollhardt, K. Peter C.
, p. 905 - 912 (2007/10/02)
η5-Cyclopentadienyl dicarbonyl cobalt catalyzes the cocyclization of 1,2-bis(propargyl)-1,2,3,4-tetrahydroisoquinolines 4b and 5 with alkynes to provide a novel synthetic entry into the tetrahydroprotoberberine nucleus.By judicious choice of trimethylsilyl substituents, regiocontrol in the D-ring can be achieved.Reaction of 4b with benzonitrile in the presence of the catalyst furnishes the rare isoquino-2,6-naphthyridine framework, also regioselectively.
