872036-46-9Relevant academic research and scientific papers
Chemoenzymatic synthesis of chiral 4-(N,N-dimethylamino)pyridine derivatives
Busto, Eduardo,Gotor-Fernandez, Vicente,Gotor, Vicente
, p. 3427 - 3435 (2005)
Chiral 4-(N,N-dimethylamino)pyridine derivatives have been prepared through a chemoenzymatic synthesis where the enzymatic kinetic resolution of a family of 4-chloro-2-(1-hydroxyalkyl)pyridines is the key step for the formation of potentially important chiral catalysts. Pseudomonas cepacia lipase (PSL) showed excellent enantioselectivity in the acylation of the (R)-enantiomers (E > 200) using vinyl acetate as acylating agent and THF as solvent, obtaining products and substrates enantiomerically pure and with excellent yields.
