872054-79-0Relevant academic research and scientific papers
COMPOUNDS FOR USE IN THE TREATMENT OF BACTERIAL INFECTION
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Page/Page column 7-8; 33-36, (2012/08/07)
This invention relates to a compound of Formula 1A: or a pharmaceutically acceptable salt thereof: wherein R1 to R4. R7, R9 to R12 and Y are as defined herein. The invention further relates to pharmaceutical composition comprising said compound or a pharm
Inhibitors of aminoglycoside 6'-N-acetyltransferases, compositions and uses thereof
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Page/Page column 7-9; 21, (2008/06/13)
The present invention relates to inhibitors of aminoglycoside 6''-N-acetyltransferases of Formula I: R-X-Y-Z Formula I wherein: R is selected from the group consisting of: R1 is selected from the group consisting of OH and R2 is selected from the group consisting of OH and R3 is selected from the group consisting of NH2 and OH; R4 is selected from the group consisting of NH2 and R5 is selected from the group consisting of OMe, OEt OPr, and O-iPr; X is selected from the group consisting of NH and O; Y is selected from the group consisting of: R6 is selected from the group consisting of OH, CH3, and OCH3; n is an integer ranging from 1 to 10; and Z is selected from the group consisting of: and R7 is selected from the group consisting of OH, OMe, OEt OPr, O-iPr, O-tBu and
Regio- and chemoselective 6′-N-derivatization of aminoglycosides: Bisubstrate inhibitors as probes to study aminoglycoside 6′-N- acetyltransferases
Gao, Feng,Yan, Xuxu,Baettig, Oliver M.,Berghuis, Albert M.,Auclair, Karine
, p. 6859 - 6862 (2007/10/03)
(Chemical Equation Presented) Complex nanomolar inhibitors in one pot: Aminoglycoside-coenzyme A derivatives were prepared through an efficient regioselective 6′-N modification of aminoglycosides (see scheme). These bisubstrates show tight-binding competi
