872166-96-6

Basic information

• Product Name: 4-amino-2-{4-(2,6-dichlorobenzylamino)phenyl}-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)1H-pyrrole-3-carbonitrile
• CAS NO: 872166-96-6
• Molecular Weight: 617.482
• Mol File: 872166-96-6.mol

Chemical Properties

• CAS DataBase Reference: 4-amino-2-{4-(2,6-dichlorobenzylamino)phenyl}-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)1H-pyrrole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-2-{4-(2,6-dichlorobenzylamino)phenyl}-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)1H-pyrrole-3-carbonitrile(872166-96-6)
• EPA Substance Registry System: 4-amino-2-{4-(2,6-dichlorobenzylamino)phenyl}-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)1H-pyrrole-3-carbonitrile(872166-96-6)

Safety Data

• Hazardous Substances Data: 872166-96-6(Hazardous Substances Data)

Upstream product

• 872166-86-4 1,1-dicyano-2-(4-methoxybenzylamino)-2-(4-nitrophenyl)ethane 
• 105590-51-0 1,1-dicyano-2-hydroxy-2-(4-nitrophenyl)ethane 
• 2393-23-9 4-methoxy-benzylamine 
• 872166-87-5 4-amino-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)-2-(4-nitrophenyl)-1H-pyrrole-3-carbonitrile 
• 872166-95-5 4-amino-2-(4-aminophenyl)-5-(2,6-difluorobenzoyl)-1-(4-methoxybenzyl)-1H-pyrrole-3-carbonitrile 
• 20443-98-5 2,6-Dichlorobenzyl bromide 

Relevant articles and documents

PYRROLE DERIVATIVE

A pyrrole derivative represented by the general formula (1): (wherein R1 represents hydrogen or C1-4 alkyl; R2 represents C1-10 alkyl, C3-10 cycloalkyl, methylenedioxyphenyl, 1,2-ethylenedioxyphenyl, 1,3-propylenedioxyphenyl, etc.; R3 and R4 are the same or different and each represents hydrogen, halogeno, C1-6 alkyl, or C1-6 alkoxy; and R5 represents hydrogen, halogeno, nitro, amino, hydroxy, C1-6 alkyl, C1-6 alkoxy, etc.) or a pharmaceutically acceptable salt of the derivative. The compounds inhibit the enzymatic activity of LcK, which participates in the abnormal activation of immunocompetent cells, and are useful for rejection reactions in organ transplantation or immune/allergic diseases such as atopic dermatitis and asthma.