872216-48-3Relevant articles and documents
The first chemical synthesis of the core structure of the benzoylhydrazine-NAD adduct, a competitive inhibitor of the Mycobacterium tuberculosis enoyl reductase
Broussy, Sylvain,Bernardes-Genisson, Vania,Quemard, Annaik,Meunier, Bernard,Bernadou, Jean
, p. 10502 - 10510 (2005)
An isoniazid-NAD adduct has been recently proposed as the ultimate metabolite responsible for the antituberculous activity of isoniazid (INH). Its structure results from binding of the isonicotinoyl radical at C4 position of the nicotinamide ring of NAD w