87223-38-9Relevant academic research and scientific papers
Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors
Gilleron, Pauline,Wlodarczyk, Nicolas,Houssin, Raymond,Farce, Amaury,Laconde, Guillaume,Goossens, Jean-Francois,Lemoine, Amelie,Pommery, Nicole,Henichart, Jean-Pierre,Millet, Regis
, p. 5465 - 5471 (2008/03/11)
A new series of FTase inhibitors containing a tricyclic moiety-dioxodibenzothiazepine or dibenzocycloheptane-has been designed and synthesized. Among them, dioxodibenzothiazepine 18d displayed significant inhibitory FTase activity (IC50 = 17.3
INTRAMOLECULAR SULFONAMIDE-CARBOXAMIDE REARRANGEMENT.
Hovius, Klaas,Wagenaar, Anno,Engberts, Jan B. F. N.
, p. 3137 - 3140 (2007/10/02)
Several o-carboxy-N,N-dialkylbenzenesulfonamides rearrange intramolecularly to o-chlorosulfonyl-N,N-dialkylbenzamides upon treatment with an excess of thionyl chloride in an apolar solvent.
