87234-57-9Relevant academic research and scientific papers
Enantioselective Synthesis of C?N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C?H Activation
Li, Honghe,Yan, Xiaoqiang,Zhang, Jitan,Guo, Weicong,Jiang, Jijun,Wang, Jun
supporting information, p. 6732 - 6736 (2019/04/17)
The first enantioselective Satoh–Miura-type reaction is reported. A variety of C?N axially chiral N-aryloxindoles have been enantioselectively synthesized by an asymmetric rhodium-catalyzed dual C?H activation reaction of N-aryloxindoles and alkynes. High yields and enantioselectivities were obtained (up to 99 % yield and up to 99 % ee). To date, it is also the first example of the asymmetric synthesis of C?N axially chiral compounds by such a C?H activation strategy.
Efficient copper-catalyzed intramolecular N-arylation for the synthesis of oxindoles
Jhan, Yu-Huei,Kang, Ting-Wei,Hsieh, Jen-Chieh
supporting information, p. 1155 - 1159 (2013/03/13)
An efficient copper-catalyzed intramolecular N-arylation was performed by using substituted 2-(2-bromoaryl)acetamide with a small amount of Cu 2O and benzene-1,2-diamine as catalytic system under aerobic conditions, which provided good to excellent yields of oxindoles with tolerance of a wide variety of substrates.
Copper-catalyzed domino coupling reaction: An efficient method to synthesize oxindoles
Hsieh, Jen-Chieh,Cheng, An-Yi,Fu, Jun-Hao,Kang, Ting-Wei
supporting information; experimental part, p. 6404 - 6409 (2012/09/05)
An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields. The Royal Society of Chemistry 2012.
CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS
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Page/Page column 87, (2016/02/02)
There are described cydohexyl amide derivatives useful as corticotropin releasing factor (CRF) receptor antagonists
Synthesis of 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives as possible nonsteroidal cardiotonics
Lee,Huang,Lin,Shih,Lee,Lin
, p. 1 - 11 (2007/10/02)
New substituted 1,3-dihydro-3,3-dimethyl-2H-indol-2-one derivatives 19-29 and 34-43 were synthesized and examined for their inotropic activity in isolated dog ventricular tissues. Among them, compound 26 (2-(2,3-dimethoxybenzylamino)-N-(3,3,7-trimethyl-2-oxo-2,3-dihydro-1H-i ndol-5-yl)acetamide) showed very potent activity.
3,3-dialkyl-and 3,3-alkylene-indoline derivatives, processes for their production and pharmaceutical compositions comprising them
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, (2008/06/13)
3,3-Dialkyl- or 3,3-alkylene-indolines which are unsubstituted at the 1- and 2-positions and which are substituted at the 4- or 6-position by an optionally etherified hydroxy group or substituted at the 5- or 7-position by an etherified hydroxy group, as well as their physiologically-hydrolyzable and -acceptable esters. The said indolines and esters as well as their pharmaceutically acceptable acid addition salts possess analgesic activity.
