872354-90-0Relevant academic research and scientific papers
Liver targeting of hepatitis-B antiviral lamivudine using the HepDirect prodrug technology
Reddy, K. Raja,Colby, Timothy J.,Fujitaki, James M.,Van Poelje, Paul D.,Erion, Mark D.
, p. 375 - 381 (2005)
A new class of phosphate and phosphonate prodrugs, called HepDirect prodrugs, has been developed to deliver drugs to the liver while simultaneously diminishing drug exposure to extra-hepatic tissues. The technology combines liver-selective cleavage and ki
RADIO-AND CHEMO-PROTECTIVE COMPOUNDS
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Paragraph 0261, (2021/11/13)
The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-l-thiol. Their use as radio- and chemo-protectors is also described.
Novel 2'-C-methyl nucleoside derivatives
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Page/Page column 63, (2008/06/13)
Compounds of Formula I, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described:
Design, Synthesis, and Characterization of a Series of Cytochrome P 450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver
Erion, Mark D.,Reddy, K. Raja,Boyer, Serge H.,Matelich, Michael C.,Gomez-Galeno, Jorge,Lemus, Robert H.,Ugarkar, Bheemarao G.,Colby, Timothy J.,Schanzer, Juergen,Van Poelje, Paul D.
, p. 5154 - 5163 (2007/10/03)
A new class of phosphate and phosphonate prodrugs, called HepDirect prodrugs, is described that combines properties of rapid liver cleavage with high plasma and tissue stability to achieve increased drug levels in the liver. The prodrugs are substituted c
