872357-90-9Relevant academic research and scientific papers
Practical highly enantioselective synthesis of propargylamines through a copper-catalyzed one-pot three-component condensation reaction
Gommermann, Nina,Knochel, Paul
, p. 4380 - 4392 (2008/02/07)
The one-pot three-component reaction of terminal alkynes, aldehydes and secondary amines in the presence of copper(1) bromide/quinap is reported. The reaction scope has been determined and a broad variety of all three components has been used, which afforded the corresponding propargylamines in good to excellent yields and moderate to very good enantioselectivities. The reaction showed a strong positive nonlinear effect. The transformation of a propargylamine intermediate into the alkaloid (S-(+)-coniine has also been described.
Preparation of functionalized primary chiral amines and amides via an enantioselective three-component synthesis of propargylamines
Gommermann, Nina,Knochel, Paul
, p. 11418 - 11426 (2007/10/03)
A general preparation of functionalized primary chiral amines and amides from propargylamines has been developed. The chirality is established by an enantioselective three-component reaction of an aldehyde, a terminal alkyne and a secondary amine in the p
