872359-50-7Relevant academic research and scientific papers
Synthesis and characterization of a new Schiff base and its metal complexes derived from the Mannich base, N-(1-piperidinobenzyl)acetamide
Raman,Ravichandran
, p. 439 - 444 (2005)
New neutral Schiff base complexes of Cu(II), Co(II), Ni(II), and Zn(II) derived from 4-aminoantipyrine and N-(1-piperidinobenzyl) acetamide (Mannich base) have been synthesized. The structural features of the complexes have been characterized by microanalytical data, IR, UV-Vis, 1H NMR, ESR, CV, TGA and powder XRD techniques. Electronic absorption spectra of the complexes indicate an octahedral geometry around the metal ion. The neutral nature of the complexes is characterized from their low molar conductance values. The cyclic voltammogram of copper complex in DMSO solution shows the process is a quasi-reversible one electron transfer. The ESR spectrum of copper complex in DMSO at 300 K and 77 K was recorded and its salient features are reported. The thermal analysis shows the absence of neither coordinated nor lattice water in all the complexes. The powder XRD pattern indicates the crystalline nature of the complexes. The antimicrobial activity of the ligand and its complexes has been extensively studied on microorganisms such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and the fungi Aspergillus niger and Rhizoctonia bataicola by well-diffusion technique using DMF as the solvent. The values of zone of inhibition were found out at 37°C for a period of 24 h. It has been found that all the complexes have higher activity than the free ligand and the standard. Copyright
