872409-96-6Relevant academic research and scientific papers
ANTIBODY-DRUG CONJUGATES
-
, (2018/05/26)
An antibody-drug conjugate (ADC) has a structure represented by Formula (I): [in-line-formulae][D2-L2-Cn2?yG2-Ab-Sg1?G1-L1-D1]x?? Formula (I)[/in-line-formulae]or a pharmaceutically acceptable salt thereof, wherein Ab is an antibody without glycans (i.e., the protein portion of an antibody);G1 and G2 are glycan moieties, which may be the same or different;Cn1 and Cn2 are conjugation moieties, which may be the same or different;L1 and L2 are linker moieties, which may be the same or different;D1 and D2 are drug units which may be the same or different; andx and y are independently an integer from 0 to 8, provided that x+y≠0.
Carbohydrate rod conjugates: Ternary rod-coil molecules forming complex liquid crystal structures
Chen, Bin,Baumeister, Ute,Pelzl, Gerhard,Das, Malay Kumar,Zeng, Xiangbing,Ungar, Goran,Tschierske, Garsten
, p. 16578 - 16591 (2007/10/03)
T-shaped polyphilic triblock molecules, consisting of a rodlike p-terphenyl unit, a hydrophilic and flexible laterally attached oligo(oxyethylene) chain terminated by an 1-acylamino-1-deoxy-D-sorbitol unit, and two end-attached lipophilic alkyl chains, have been synthesized by palladium-catalyzed cross-coupling reactions as the key steps. The thermotropic liquid crystalline behavior of these compounds was investigated by polarized light microscopy, differential scanning calorimetry (DSC), and X-ray scattering. We investigated the mode of self-organization as a function of the length and position of the lateral polar chain and the length of the terminal alkyl chains. Depending on the size of the polar and lipophilic segments, a series of unusual liquid crystalline phases was detected. In three of these phases, the space is divided into three distinct periodic subspaces. In addition to a hexagonal channeled layer phase (ChLhex) consisting of layers that are penetrated by polar columns, there are also two honeycomb-like network structures formed by square (Colsqu/p4mm) or pentagonal cylinders (Colsqu/p4gm) . The cylinder walls consist of the terphenyl units fused by columns of alkyl chains, and the interior contains the polar side chains. In addition, a hexagonal columnar phase was observed in which the polar columns are organized in a continuum of terphenyls and alkyl chains with an organization of the terphenyl cores tangentially around the columns with the long axis perpendicular to the columns. For one compound, a reversal of birefringence was observed, which is explained by a reorientation of the terphenyl cores. The addition of protic solvents induces lamellar phases.
Supramolecular dendrimers: Unusual mesophases of ionic liquid crystals derived from protonation of DAB dendrimers with facial amphiphilic carboxylic acids
Cook, Andrew G.,Baumeister, Ute,Tschierske, Carsten
, p. 1708 - 1721 (2008/12/20)
Supramolecular liquid crystalline (LC) dendrimers were prepared by self-assembly of first to fifth generation amino terminated DAB dendrimers with facial amphiphilic carboxylic acids. These carboxylic acids are composed of three distinct incompatible segm
Liquid crystals with complex superstructures
Chen, Bin,Zeng, Xiang Bing,Baumeister, Ute,Diele, Siegmar,Ungar, Goran,Tschierske, Carsten
, p. 4621 - 4625 (2007/10/03)
The hexagonal-channeled layer phase (ChLhex; see picture, right) is one of the new liquid-crystalline phases formed by the self-organization of the rigid rodlike alkali-metal carboxylates shown.
