872415-94-6Relevant academic research and scientific papers
Synthesis of biphenylamines via Suzuki-Miyaura cross-coupling reactions
Maj, Anna M.,Delaude, Lionel,Demonceau, Albert,Noels, Alfred F.
, p. 2657 - 2663 (2007)
A small library of meta- and para-biphenylamines substituted by various alkyl, alkoxy, phenoxy, or halogeno groups on their aromatic rings was synthesized via Suzuki-Miyaura cross-coupling between bromoanilines and arylboronic acids using palladium cataly
Synthesis and biological evaluation of chiral α-aminoanilides with central antinociceptive activity
Corbo, Filomena,Franchini, Carlo,Lentini, Giovanni,Muraglia, Marilena,Ghelardini, Carla,Matucci, Rosanna,Galeotti, Nicoletta,Vivoli, Elisa,Tortorella, Vincenzo
, p. 1907 - 1915 (2008/02/01)
Tocainide and related optically active chiral α-aminoanilides were synthesized and tested in vivo via the hot plate test to evaluate their central analgesic action. The aims of the study were to verify if a) the increase in lipophilicity, obtained by the introduction of an alkyl group on the steric center (3f-i), and the replacement of the C=O group with the C=S (10) group as well as the introduction of a methyl or ethyl group on the amidic nitrogen atom (8a-c) would produce an increase in central analgesic efficacy with respect to Tocainide; b) the 2,6-xylidide moiety is crucial for high analgesic activity (3b-e); c) the hydrogen atom bonded to the amidic nitrogen moiety is an essential pharmacophoric element for analgesic activity. Among all the synthesized compounds, 3f showed antinociceptive properties with a good enantioselective index.
