872459-74-0Relevant academic research and scientific papers
Pyridine and pyridinone-based factor XIa inhibitors
Corte, James R.,Fang, Tianan,Hangeland, Jon J.,Friends, Todd J.,Rendina, Alan R.,Luettgen, Joseph M.,Bozarth, Jeffrey M.,Barbera, Frank A.,Rossi, Karen A.,Wei, Anzhi,Ramamurthy, Vidhyashankar,Morin, Paul E.,Seiffert, Dietmar A.,Wexler, Ruth R.,Quan, Mimi L.
, p. 925 - 930 (2015/02/19)
The structure-activity relationships (SAR) of six-membered ring replacements for the imidazole ring scaffold is described. This work led to the discovery of the potent and selective pyridine (S)-23 and pyridinone (±)-24 factor XIa inhibitors. SAR and X-ra
