872459-80-8

Basic information

• Product Name: [(S)-2-phenyl-1-(4-phenyl-pyrimidin-2-yl)-ethyl]-carbamic acid tert-butyl ester
• Synonyms: [(S)-2-phenyl-1-(4-phenyl-pyrimidin-2-yl)-ethyl]-carbamic acid tert-butyl ester
• CAS NO: 872459-80-8
• Molecular Weight: 375.47
• Mol File: 872459-80-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(S)-2-phenyl-1-(4-phenyl-pyrimidin-2-yl)-ethyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-2-phenyl-1-(4-phenyl-pyrimidin-2-yl)-ethyl]-carbamic acid tert-butyl ester(872459-80-8)
• EPA Substance Registry System: [(S)-2-phenyl-1-(4-phenyl-pyrimidin-2-yl)-ethyl]-carbamic acid tert-butyl ester(872459-80-8)

Safety Data

• Hazardous Substances Data: 872459-80-8(Hazardous Substances Data)

Upstream product

• 872459-79-5 ((S)-1-carbamimidoyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 3623-15-2 phenyl propargyl ketone 

Downstream Products

• 872459-81-9 (S)-2-phenyl-1-(4-phenylpyrimidin-2-yl)ethanamine 

Relevant articles and documents

SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS

The present invention provides compounds of Formula (I) or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, X1, X2, X3, X4, and X5 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.