87248-13-3Relevant academic research and scientific papers
Preparation of aminocyclopentane acids
-
, (2008/06/13)
A process is described for the preparation of compounds of the formula STR1 in which W is C1-7 alkylene X is cis or trans --CH=CH-- or --CH2 Ch2 -- Y is a saturated heterocyclic amino group, and R2 is substituted or unsubstituted phenyl-, thienyl- or naphthyl-alkyl, or cinnamyl, and their salts and solvates. The process comprises hydrolysing a corresponding ester, amide, nitrile or ortho-ester. The starting materials are preferably prepared by reducing the corresponding cyclopentanone and hydrolysis can take place simultaneously with reduction.
Preparation of a piperidinylcyclopentylheptenoic acid derivative
-
, (2008/06/13)
A process is described for the preparation of a compound of formula (1) STR1 or a salt thereof, which comprises reacting a compound of formula (2) STR2 (where A is a displaceable atom or group and R is a hydrogen atom or a C1-6 alkyl or C7-20 aralkyl protecting group) or a salt thereof, to replace the moiety A with a phenyl group, followed where necessary by removal of a C1-6 alkyl or C7-20 aralkyl protecting group and/or by salt formation. The replacement of A in formula (2) by a phenyl group may be effected with a compound PhX (3) wherein Ph represents a phenyl and X is an atom or group as defined for A in formula (2) or X is a metal atom or metal-containing group or a group SiR'3 (where R' is an alkyl or aryl group) provided that when A is --B(OH)2 X can only represent a conventional leaving group.
Preparation of piperidinylcyclopentylheptenoic acid derivatives
-
, (2008/06/13)
A process is described for the preparation of a compound of formula (2) STR1 (wherein R is a C1-6 alkyl or a C7-20 aralkyl group) and the salts thereof, which comprises reducing a compound of formula (3) STR2 (or a salt thereof), using a reducing system comprising borohydride ions and metal ions selected from lanthanide ions, alkaline earth metal ions or yttrium ions in solution. The reduction system may be provided by a borohydride (e.g. NaBH4) and a metal salt (e.g. CeCl3). The ester (2) may then if desired be hydrolyzed to give the parent acid.
