87248-13-3

Basic information

• Product Name: GR 32191B
• Synonyms: D-GLUCOSAMINE N2,3,6-TRISULFATE, SODIUM;(4z)-7-[(1r,2r,3s,5s)-5-([1,1'-biphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid hydrochloride;Vapiprost hydrochloride
• CAS NO: 87248-13-3
• Molecular Formula: C30Cl1H40N1O4
• Molecular Weight: 514.1
• Mol File: 87248-13-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 127-128 °C
• Boiling Point: 649.3°Cat760mmHg
• Flash Point: 346.5°C
• Appearance: off-white/solid
• Density: 1.18g/cm³
• Storage Temp.: −20°C
• Solubility: H2O: ~16 mg/mL
• CAS DataBase Reference: GR 32191B(CAS DataBase Reference)
• NIST Chemistry Reference: GR 32191B(87248-13-3)
• EPA Substance Registry System: GR 32191B(87248-13-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 87248-13-3(Hazardous Substances Data)

Relevant articles and documents

Preparation of aminocyclopentane acids

A process is described for the preparation of compounds of the formula STR1 in which W is C1-7 alkylene X is cis or trans --CH=CH-- or --CH2 Ch2 -- Y is a saturated heterocyclic amino group, and R2 is substituted or unsubstituted phenyl-, thienyl- or naphthyl-alkyl, or cinnamyl, and their salts and solvates. The process comprises hydrolysing a corresponding ester, amide, nitrile or ortho-ester. The starting materials are preferably prepared by reducing the corresponding cyclopentanone and hydrolysis can take place simultaneously with reduction.

Preparation of piperidinylcyclopentylheptenoic acid derivatives

A process is described for the preparation of a compound of formula (2) STR1 (wherein R is a C1-6 alkyl or a C7-20 aralkyl group) and the salts thereof, which comprises reducing a compound of formula (3) STR2 (or a salt thereof), using a reducing system comprising borohydride ions and metal ions selected from lanthanide ions, alkaline earth metal ions or yttrium ions in solution. The reduction system may be provided by a borohydride (e.g. NaBH4) and a metal salt (e.g. CeCl3). The ester (2) may then if desired be hydrolyzed to give the parent acid.