872509-56-3

Basic information

• Product Name: 2,6-Dichloro-3,5-dimethoxyaniline
• Synonyms: 2,6-Dichloro-3,5-dimethoxyaniline;2,6-Dichloro-3,5-dimethoxybenzenamine;Benzenamine, 2,6-dichloro-3,5-dimethoxy-;2,6-Dichloro-3,5-dimethoxy-phenylamine
• CAS NO: 872509-56-3
• Molecular Formula: C₈H₉Cl₂NO₂
• Molecular Weight: 222.06856
• Mol File: 872509-56-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 320℃
• Flash Point: 147℃
• Appearance: /
• Density: 1.357
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.13±0.10(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-3,5-dimethoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-3,5-dimethoxyaniline(872509-56-3)
• EPA Substance Registry System: 2,6-Dichloro-3,5-dimethoxyaniline(872509-56-3)

Safety Data

• Hazardous Substances Data: 872509-56-3(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-3,5-dimethoxyaniline, also known as dichloroaniline, is a chemical compound with the molecular formula C8H9Cl2NO2. It is an organic compound belonging to the aniline family and is used in the production of dyes and pigments. The compound is a pale yellow to brownish solid and is primarily used as an intermediate in the synthesis of pharmaceuticals and agricultural chemicals. 2,6-Dichloro-3,5-dimethoxyaniline is considered to be moderately toxic and can cause irritation to the skin, eyes, and respiratory system upon exposure. It is important to handle this chemical with caution and proper safety measures in place.

Upstream product

• 943189-21-7 N-(2,6-dichloro-3,5-dimethoxy-phenyl)-acetamide 
• 79257-61-7 N-(3,5-dimethoxy-phenyl)-acetamide 
• 10272-07-8 3.5-dimethoxyaniline 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 75177-59-2 2,6-dichloro-3,5-dimethoxybenzoic acid 

Downstream Products

• 1093960-59-8 4-chloro-N-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline-8-carboxamide 
• 1802253-30-0 1-(6-chloropyrimidin-4-yl)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylurea 

Relevant articles and documents

Preparation method of kinase inhibitor intermediate

The invention relates to a synthetic method of a kinase inhibitor intermediate, namely 2, 6-dichloro-3, 5-methoxyaniline (I), belongs to the field of organic synthesis, and has the advantages of safeand stable route, convenience in operation, easiness in

Pyrido[2,3-b]pyrazine-3(4H)-ketone derivative and application thereof

The invention provides a pyrido[2,3-b]pyrazine-3(4H)-ketone derivative and application thereof. The structural general formula of the pyrido[2,3-b]pyrazine-3(4H)-ketone derivative is a formula V, andthe pyrido[2,3-b]pyrazine-3(4H)-ketone derivative comprises pharmaceutically acceptable salt, solvate, hydrate or crystal form thereof. The compound provided by the invention is an active ligand of afibroblast growth factor receptor (FGFR), and research shows that the compound shown in the structure V has good anti-proliferative activity on KATO III gastric cancer cells (FGFR2 amplification) andHuh-7 liver cancer cells (FGFR4 overexpression), and is applied to preparation of drugs for treating tumor-related diseases caused by FGFR abnormal activation as an FGFR inhibitor. The structural general formula V is shown in the description.

BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS

The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in the treatment of FGFR4-associated diseases such as cancer.