872513-33-2

Upstream product

• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 872513-28-5 3-(5-bromo-2-methoxy-phenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine 
• 872513-29-6 [3-(5-bromo-2-methoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2,4-difluoro-phenyl)-amine 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 872513-27-4 (5-bromo-2-methoxy-phenyl)-(2,4-dichloro-pyrimidin-5-yl)-methanone 
• 872513-54-7 (5-bromo-2-methoxy-phenyl)-(2,4-dichloro-pyrimidin-5-yl)-methanol 

Relevant academic research and scientific papers

Pyrazoloheteroaryls: Novel p38α MAP kinase inhibiting scaffolds with oral activity

A test library with three novel p38α inhibitory scaffolds and a narrow set of substituents was prepared. Appropriate combination of substituent and scaffold generated potent p38α inhibitors, for example, pyrazolo[3,4-b]pyridine 9, pyrazolo[3,4-d]pyrimidin

PYRAZOLO-HETEROARYL COMPOUNDS USEFUL TO TREAT TNF-ALPHA AND IL-1 MEDIATED DISEASES

A compound of formula (I) wherein the groups R1-R4, X and Y are as defined in the specification, useful to treat TNF-Alpha and IL-1 mediated diseases.