872576-64-2

Basic information

• Product Name: 4(5H)-Thiazolone, 2-[[(1R,2S)-2-phenylcyclopropyl]amino]-
• CAS NO: 872576-64-2
• Molecular Formula: C12H12N2OS
• Molecular Weight: 232.306
• Mol File: 872576-64-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4(5H)-Thiazolone, 2-[[(1R,2S)-2-phenylcyclopropyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(5H)-Thiazolone, 2-[[(1R,2S)-2-phenylcyclopropyl]amino]-(872576-64-2)
• EPA Substance Registry System: 4(5H)-Thiazolone, 2-[[(1R,2S)-2-phenylcyclopropyl]amino]-(872576-64-2)

Safety Data

• Hazardous Substances Data: 872576-64-2(Hazardous Substances Data)

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 1986-47-6 tranylcypromine hydrochloride 
• 95-62-5 (1R,2S)-1-amino-2-phenylcyclopropane 

Downstream Products

• 872576-61-9 4-methoxy-6-[4-oxo-2-((1R,2S)-2-phenyl-cyclopropylamino)-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors

A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK1 activity in vitro, and block cell cycle progression in human tumor cell lines, suggesting a potential use as antitumor agents.

Thiazolinone 2-substituted quinolines

Thiazolinone substituted quinoline derivatives where the quinoline ring is substituted at the 2 position which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents.

Quinazoline thiazolinones

Quinazoline thiazolinone derivatives which demonstrate CDK1 antiproliferative activity and are useful as anti-cancer agents.