872690-44-3Relevant academic research and scientific papers
Cobalt-Catalyzed Selective Functionalization of Aniline Derivatives with Hexafluoroisopropanol
Zhao, He,Zhao, Shuo,Li, Xiu,Deng, Yinyue,Jiang, Huanfeng,Zhang, Min
, p. 218 - 222 (2019)
A cobalt-catalyzed site-selective functionalization of aniline derivatives with hexafluoroisopropanol, which enables the synthesis of a wide array of fluoroalkylated anilines, a class of highly valuable building blocks for further preparation of fluorinated functional products, is reported. The developed transformation proceeds with operational simplicity, use of earth-abundant metal catalyst, broad substrate scope, good functional group tolerance, and mild reaction conditions.
Novel hexafluoroisopropanol derivatives
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Page/Page column 11, (2008/06/13)
The invention is concerned with novel hexafluoroisopropanol derivatives of formula (I) wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. The
Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRα and β
Panday, Narendra,Benz, Joerg,Blum-Kaelin, Denise,Bourgeaux, Vanessa,Dehmlow, Henrietta,Hartman, Peter,Kuhn, Bernd,Ratni, Hassen,Warot, Xavier,Wright, Matthew B.
, p. 5231 - 5237 (2007/10/03)
A series of branched and unbranched anilinohexafluoroisopropanols related to the known sulfonamide T0901317 were prepared and evaluated as activators/modulators of both LXRα and LXRβ. A structure-activity relationship was established and compounds with high potency on both the receptors were identified. Many compounds showed a tendency toward selectivity for LXRβ versus LXRα. Several analogues were evaluated for effects on plasma lipoprotein levels in mice. A few of these significantly raised HDL-cholesterol levels in plasma but showed markedly different effects on liver triglyceride content, suggesting that this series may yield candidates with improved efficacy/safety profiles compared to existing molecules.
