87273-60-7Relevant academic research and scientific papers
STRUCTURE AND REACTIVITY OF 2-METHYL-9-HYDROXY-4H-PYRIDOPYRIMIDIN-4-ONE
Smirnov, L. D.,Nikitin, S. V.,Chernyshev, A. I.,Sorokin, A. A.,Lezina, V. P.,et al.
, p. 1425 - 1431 (1992)
It has been shown that the alkylation of 2-methyl-9-hydroxy-4H-pyridopyrimidin-4-one takes place at the oxygen atom, but electrophilic substitution takes place mainly at position 8 of the molecule (the ortho position relative to the hydroxy group).
2-methyl-3-chloro-9-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine hydrochloride: Crystal structure and interaction with DNA
Zhang, Huaihong,Huang, Rong,Cai, Zhaosheng,Xu, Chunxiang,Sun, Baiwang
, p. 70 - 75 (2013)
The title compound, C9H8ClN2O2 +·Cl-, is a hydrochloric acid salt of 2-methyl-3-chloro-9- hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one, which is an important intermediate for the synthesis of biologically active heterocyclic compounds. The synthesized compound was characterized by 1H NMR and X-ray crystallography. The structure was solved in monoclinic, space group P21/n with a = 11.8295 (12), b = 6.2214 (6), c = 13.8133 (15) A?, β = 97.7860 (10) , V = 1007.23 (18) A?3, Z = 4, and with R int = 0.077. The cation of the title compound, as shown by the single-crystal structure determination, has two conjugated aromatic rings that are almost coplanar with a dihedral angle of 0.230. The crystal packing is stabilized by intermolecular N-H···Cl, O- H···Cl hydrogen bonds, which link the molecules into centrosymmetric dimers, and by weak π-π stacking interactions (average distance 3.352 A?). The interaction of native calf thymus DNA (ctDNA) with the compound at physiological pH was monitored by UV-Vis spectroscopy and viscosimetric techniques. It was found that the compound might interact with ctDNA by a groove mode of binding via hydrogen bonds.
NITROGEN BRIDGEHEAD COMPOUNDS PART 39. SYNTHESIS AND REACTIONS OF 3-PHENOXY-2-METHYL-4H-PYRIDOPYRIMIDIN-4-ONES
Balogh, Maria,Hermecz, Istvan,Szilagyi, Ildiko,Meszaros, Zoltan
, p. 1083 - 1088 (2007/10/02)
3-Phenoxy- and 3-chloro-2-methyl-4H-pyridopyrimidin-4-ones (2) and (5) were prepared by the reactions of 2-aminopyridines and 2-phenoxy- or 2-chloroacetatoacetate (4) and (7) in a mixture of phosphoryl chloride -- polyphosphoric acid.The ring-trans
