87274-98-4

Basic information

• Product Name: N-[(2Z)-1,5-dimethyl-3,3-diphenylpyrrolidin-2-ylidene]acetamide
• Synonyms: (+-)-N-(1,5-Dimethyl-3,3-diphenyl-2-pyrrolidinylidene)acetamide; Acetamide, N-(1,5-dimethyl-3,3-diphenyl-2-pyrrolidinylidene)-, (+-)-
• CAS NO: 87274-98-4
• Molecular Formula: C₂₀H₂₂N₂O
• Molecular Weight: 306.4015
• Mol File: 87274-98-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 432.6°C at 760 mmHg
• Flash Point: 215.5°C
• Density: 1.07g/cm³
• Vapor Pressure: 1.09E-07mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: N-[(2Z)-1,5-dimethyl-3,3-diphenylpyrrolidin-2-ylidene]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(2Z)-1,5-dimethyl-3,3-diphenylpyrrolidin-2-ylidene]acetamide(87274-98-4)
• EPA Substance Registry System: N-[(2Z)-1,5-dimethyl-3,3-diphenylpyrrolidin-2-ylidene]acetamide(87274-98-4)

Safety Data

• Hazardous Substances Data: 87274-98-4(Hazardous Substances Data)

Upstream product

• 101722-14-9 4-cyano-2-methyl-4,4-diphenyl-butyryl azide 
• 101731-10-6 4-isocyanato-2,2-diphenyl-valeronitrile 
• 101792-61-4 4-cyano-2-methyl-4,4-diphenyl-butyric acid amide 
• 87274-94-0 (+/-)-4-(N-carbomethoxy-N-methylamino)-2,2-diphenylvaleronitrile 
• 86-29-3 Diphenylacetonitrile 
• 17268-74-5 (+/-)-2-imino-1,5-dimethyl-3,3-diphenylpyrrolidine hydrochloride 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Synthesis and anticonvulsant screening of 3,3-diphenyl-2-pyrrolidone derivatives

Six derivatives of 3,3-diphenyl-2-pyrrolidone were synthesized and screened for anticonvulsant activity. The synthetic route involved a mono-N-demethylation of an intermediate N,N-dimethylaminonitrile with methyl chloroformate followed by cleavage of the carbamate group. Of the six derivatives, (±)-2-imino-1,5-dimethyl-3,3-diphenylpyrrolidine hydrochloride was effective in protecting mice against maximal electroshock (MES)-induced seizures at a 30-mg/kg dose level.