87280-01-1Relevant articles and documents
A Short and Efficient Synthesis of the [3]Triangulene Ring System
Holt, Carter J.,Wentworth, Katelyn J.,Johnson, Richard P.
, p. 15793 - 15796 (2019)
Triangulenes are of current interest for potential applications in molecular electronics. We describe here a three step synthesis of the 4,8,12-trihydro[3]triangulenium cation by cascade cyclization of a tetra-benzyl alcohol precursor in triflic acid solu
Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates
Doobary, Sayad,Sedikides, Alexi T.,Caldora, Henry P.,Poole, Darren L.,Lennox, Alastair J. J.
supporting information, p. 1155 - 1160 (2019/12/11)
Fluorinated alkyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochemical generation of a hypervalent iodine mediator using an “ex-cell” approach, which avoids oxidative substrate decomposition. The more sustainable conditions give good to excellent yields in up to decagram scales.
Selectivity in the tandem cyclization - Carboxylation reaction of unsaturated haloaryl ethers catalyzed by electrogenerated nickel complexes
Olivero,Du?ach
, p. 1885 - 1891 (2007/10/03)
The electrochemical reduction of a series of 2-haloaryl ethers containing allyl and propargyl groups under CO2 allows the synthesis of benzofuranacetic acid derivatives. This novel intramolecular cyclization- carboxylation reaction is carried out in single-compartment cells and is catalyzed by [Ni(cyclam)Br2].