87282-04-0

Basic information

• Product Name: 3,5-dimethoxy-N-phenylbenzamide
• Synonyms: 3,5-dimethoxy-N-phenylbenzamide
• CAS NO: 87282-04-0
• Molecular Formula: C₁₅H₁₅NO₃
• Molecular Weight: 257.2845
• Mol File: 87282-04-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,5-dimethoxy-N-phenylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethoxy-N-phenylbenzamide(87282-04-0)
• EPA Substance Registry System: 3,5-dimethoxy-N-phenylbenzamide(87282-04-0)

Safety Data

• Hazardous Substances Data: 87282-04-0(Hazardous Substances Data)

Upstream product

• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 62-53-3 aniline 
• 694-59-7 pyridine N-oxide 
• 87281-99-0 3,5-Dimethoxy-N-phenyl-benzimidoyl chloride 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 142-04-1 aniline hydrochloride 
• 108-86-1 bromobenzene 
• 17213-58-0 3,5-dimethoxybenzamide 
• 591-50-4 iodobenzene 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 98-95-3 nitrobenzene 
• 103-71-9 phenyl isocyanate 
• 64-10-8 phenyl carbamate 
• 91-52-1 2,4 dimethoxybenzoic acid 

Downstream Products

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 16909-11-8 3-(3,5-dimethoxyphenyl)acrylic acid 

Relevant articles and documents

Amide bond synthesis via silver(I) N-heterocyclic carbene-catalyzed and tert-butyl hydroperoxide-mediated oxidative coupling of alcohols with amines under base free conditions

We present a base free method for amide bond construction via oxidative coupling of alcohols with amines catalyzed by Silver(I) N-heterocyclic carbenes (Ag(I)-NHCs) and mediated by tert-butyl hydroperoxide (TBHP) in ethanol. The results of controlled experiments suggest that the oxidative coupling proceeds through the formation of aldehyde, then subsequent attack by amine to give hemiaminal, which can then be oxidized to amide.

Interpositus substituted N-aryl benzoyl amines one-step synthesis method of the compound

The invention discloses a one-step synthetic method of meta-substituted N-arylbenzamide compounds. Transition metal ruthenium is used as a catalyst, and the meta-substituted N-arylbenzamide compounds are synthesized in one step through carboxy-based o-C-H functionalization/ decarboxylation coupling reaction of aromatic acid and phenyl isocyanate compounds. The method has the advantages that the raw materials are simple and readily available, the catalyst is cheap, the reaction operation is simple, the utilization rate of atoms is high, the method is environment-friendly and the like.

Ru(II)-catalyzed ortho-amidation and decarboxylation of aromatic acids: A versatile route to meta-substituted N-aryl benzamides

Carboxylate as a promising and valuable directing group has attracted a great deal of attention. However, employing it as a traceless direction group has rarely been reported. We developed the ruthenium-catalyzed amidation of substituted benzoic acids wit

Base-catalyzed synthesis of amides and imines via C-C and CC bond cleavage

A transition metal free base catalyzed approach for C-N bond formation via C-C and CC bond activation has been developed. The N-arylureas reacted smoothly with 1,3-dicarbonyls and α,β-unsaturated ketones to furnish the corresponding amides and imines respectively in moderate to excellent yields.

A convenient synthesis of N-aryl benzamides by rhodium-catalyzed ortho-amidation and decarboxylation of benzoic acids

The rhodium-catalyzed amidation of substituted benzoic acids with isocyanates by directed C-H functionalization followed by decarboxylation to afford the corresponding N-aryl benzamides is demonstrated, in which the carboxylate serves as a unique, removable directing group. Notably, less common meta-substituted N-aryl benzamides are generated readily from more accessible paraor ortho-substituted groups by employing this strategy.

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Facile cuI-catalyzed arylation of azoles and amides using simple enaminones as efficient ligands

(E)-3-(Dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one was found to be an excellent ligand for copper-catalyzed N-arylation of azoles and amides with aryl halides under mild conditions. The reaction took place at 82 C in MeCN with broad functional-group compatibility. A combination of the ligand and CuI proved to be an efficient catalytic system to promote the coupling reactions of aryl halides with azoles and amides.

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