872825-04-2Relevant academic research and scientific papers
Structure-activity relationships of heteroaromatic esters as human rhinovirus 3C protease inhibitors
Im, Isak,Lee, Eui Seung,Choi, Soo Jeong,Lee, Ju-Yeon,Kim, Yong-Chul
scheme or table, p. 3632 - 3636 (2010/03/24)
Human rhinovirus 3C protease (HRV 3Cpro) is known to be a promising target for development of therapeutic agents against the common cold because of the importance of the protease in viral replication as well as its expression in a large number of serotypes. To explore non-peptidic inhibitors of HRV 3Cpro, a series of novel heteroaromatic esters was synthesized and evaluated for inhibitory activity against HRV 3Cpro, to determine the structure-activity relationships. The most potent inhibitor, 7, with a 5-bromopyridinyl group, had an IC50 value of 80 nM. In addition, the binding mode of a novel analog, 19, with the 4-hydroxyquinolinone moiety, was explored by molecular docking, suggesting a new interaction in the S1 pocket.
