872826-86-3

Basic information

• Product Name: 2,6-dimethyl-3-o-tolyl-3H-quinazolin-4-one
• CAS NO: 872826-86-3
• Molecular Weight: 264.327
• Mol File: 872826-86-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-dimethyl-3-o-tolyl-3H-quinazolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-3-o-tolyl-3H-quinazolin-4-one(872826-86-3)
• EPA Substance Registry System: 2,6-dimethyl-3-o-tolyl-3H-quinazolin-4-one(872826-86-3)

Safety Data

• Hazardous Substances Data: 872826-86-3(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 67081-68-9 2-acetamido-5-methylbenzoic acid 
• 62175-49-9 2-methyl-6-methyl-4H-3,1-benzoxazin-4-one 
• 2941-78-8 2-Amino-5-methylbenzoic acid 

Relevant articles and documents

Atropisomeric quinazolin-4-one derivatives are potent noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists

Piriqualone (1) was found to be an antagonist of AMPA receptors. Structure-activity optimization was conducted on each of the three rings in 1 to afford a series of potent and selective antagonists. The sterically crowded environment surrounding the N-3 aryl group provided sufficient thermal stability for atropisomers to be isolated. Separation of these atropisomers resulted in the identification of (+)-38 (CP-465,022), a compound that binds to the AMPA receptor with high affinity (IC50 = 36 nM) and displays potent anticonvulsant activity.