872886-96-9

Basic information

• Product Name: Furo[2,3-b]pyridine-2-carboxamide, 3-amino-N-phenyl-
• CAS NO: 872886-96-9
• Molecular Formula: C14H11N3O2
• Molecular Weight: 253.26
• Mol File: 872886-96-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Furo[2,3-b]pyridine-2-carboxamide, 3-amino-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-b]pyridine-2-carboxamide, 3-amino-N-phenyl-(872886-96-9)
• EPA Substance Registry System: Furo[2,3-b]pyridine-2-carboxamide, 3-amino-N-phenyl-(872886-96-9)

Safety Data

• Hazardous Substances Data: 872886-96-9(Hazardous Substances Data)

Upstream product

• 4746-61-6 glycolanilide 
• 62-53-3 aniline 

Relevant articles and documents

Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives

Forty seven thieno[2,3-b]pyridines-2-carboxamides, furo[2,3-b]pyridines-2-carboxamides and tetrahydrothieno[2,3-b]quinolones-2-carboxamides derivatives were synthesized and tested for their antiproliferative activity against the NCI-60 cell lines. The 5-keto-tetrahydrothieno[2,3-b]quinolones-2-carboxamides (series 17) were found to have the greatest activity, with the compound containing a 3-methoxyphenylcarboxamide (compound 17d) being the most active, with GI50values in the low nanomolar range against a range of cell lines, in particular the melanoma cell line MDA-MD-435 (GI50- 23 nM) and the breast cancer cell line MDA-MB-468 (GI50- 46 nM). Molecular modelling of series 17 against phosphoinositide specific-phospholipase C reveals that the side chains of the amino acids His356, Glu341, Arg549 and Lys438 are involved in hydrogen bonding with the ligands as well as a lipophilic pocket is occupied by the phenyl carboxamide moiety.