872891-63-9Relevant academic research and scientific papers
Chemistry of 1,2,4-trioxanes: Base-mediated formation of highly reactive electrophiles and their entrapment with amines and thiols
Singh, Chandan,Malik, Heetika
, p. 3485 - 3489 (2008/02/10)
6-(1-Arylvinyl)-substituted 1,2,4-trioxanes undergo a highly facile fragmentation under mild basic conditions to furnish 3-aryl-1-hydroxybut-3-en-2- ones, which react very efficiently with various amines and thiols to give Michael adducts. Both the formation of the reactive 3-aryl-1-hydroxybut-3-en-2- ones and their subsequent reaction with amines and thiols can be achieved in one pot. Georg Thieme Verlag Stuttgart.
