872980-35-3Relevant academic research and scientific papers
C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization
Robinson, Ralph P.,Mascitti, Vincent,Boustany-Kari, Carine M.,Carr, Christopher L.,Foley, Patrick M.,Kimoto, Emi,Leininger, Michael T.,Lowe, Andre,Klenotic, Michelle K.,MacDonald, James I.,Maguire, Robert J.,Masterson, Victoria M.,Maurer, Tristan S.,Miao, Zhuang,Patel, Jigna D.,Préville, Cathy,Reese, Matthew R.,She, Li,Steppan, Claire M.,Thuma, Benjamin A.,Zhu, Tong
scheme or table, p. 1569 - 1572 (2010/06/20)
Modifications to the sugar portion of C-aryl glycoside sodium glucose transporter 2 (SGLT2) inhibitors were explored, including systematic deletion and modification of each of the glycoside hydroxyl groups. Based on results showing activity to be quite to
Methylidene-D-xylopyranosyl- and oxo-D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
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Page/Page column 17, (2008/06/13)
D-Xylopyranosyl-substituted phenyls of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotran
D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
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Page/Page column 16-17, (2010/02/15)
A D-Xylopyranosyl-substituted phenyl compound of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.
