872983-40-9Relevant academic research and scientific papers
Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors
Gilbert, Eric J.,Zhou, Guowei,Wong, Michael K.C.,Tong, Ling,Shankar, Bandarpalle B.,Huang, Chunli,Kelly, Joseph,Lavey, Brian J.,McCombie, Stuart W.,Chen, Lei,Rizvi, Razia,Dong, Youhao,Shu, Youheng,Kozlowski, Joseph A.,Shih, Neng-Yang,Hipkin, R. William,Gonsiorek, Waldemar,Malikzay, Asra,Lunn, Charles A.,Favreau, Len,Lundell, Daniel J.
scheme or table, p. 608 - 611 (2010/05/02)
The triaryl bis-sulfone 1 was modified by converting the aryl A-ring to a piperidine ring. The piperidine ring was further elaborated to a spirocyclopropyl piperidine moiety. The effect on CB2 binding potency, rat calcium channel affinity, and CYP 2C9 inh
CANNABINOID RECEPTOR LIGANDS
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Page/Page column 55; 58, (2008/06/13)
Compounds of Formula (I) and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be effective asCB2 receptor ligands in treating cancer and inflammatory, immunomodulatory or respiratory diseases or conditions.
