872988-85-7Relevant academic research and scientific papers
Dual PPAR-α and -γ activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential
Madhavan, Gurram R.,Chakrabarti, Ranjan,Anantha Reddy,Rajesh,Balraju,Bheema Rao,Rajagopalan,Iqbal, Javed
, p. 584 - 591 (2007/10/03)
2,4-Thiazolidinedione derivatives of 1,3-benzoxazinone were synthesized and evaluated for their PPAR-α and -γ dual activation. DRF-2519, a compound obtained through SAR of TZD derivatives of benzoxazinone, has shown potent dual PPAR activation. In ob/ob mice, it showed better efficacy than the comparator molecules. In fat fed rat model, it showed significant improvement in lipid parameters, which was better than fibrates.
