872993-05-0 Usage
Uses
Used in Pharmaceutical Industry:
Resolvin D1 is used as a therapeutic agent for the treatment of inflammatory conditions. Its potent anti-inflammatory properties make it a promising candidate for the management of various diseases characterized by chronic inflammation, such as rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis.
Used in Cardiovascular Applications:
Resolvin D1 is used to protect against hepatic injury and heart failure, specifically in rats. Its cardioprotective effects are attributed to its ability to modulate inflammatory pathways and promote the resolution of inflammation in the heart and liver tissues.
Used in Anti-Inflammatory Applications:
Resolvin D1 is used as a means to attenuate the inflammatory reaction. It has been shown to reduce the production of pro-inflammatory mediators and promote the expression of anti-inflammatory molecules, leading to the resolution of inflammation and tissue repair.
Check Digit Verification of cas no
The CAS Registry Mumber 872993-05-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,2,9,9 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 872993-05:
(8*8)+(7*7)+(6*2)+(5*9)+(4*9)+(3*3)+(2*0)+(1*5)=220
220 % 10 = 0
So 872993-05-0 is a valid CAS Registry Number.
872993-05-0Relevant academic research and scientific papers
Stereocontrolled synthesis of resolvin D1
Morita, Masao,Wu, Shangze,Kobayashi, Yuichi
, p. 2212 - 2222 (2019/02/27)
We studied the synthesis of RvD1, a pro-resolving mediator. The intermediate containing vic-diol and enal functional groups was prepared via the oxidation of the γ,δ-epoxy alcohol followed by the epoxide ring opening in one pot. The C11-aldehyde in the resulting enal was converted to the trans iodo-olefin by reaction with TMSC(N2)Li and subsequent hydrozirconation using in situ generated Cp2Zr(H)Cl followed by iodination. The trans enynyl alcohol was synthesized by the reaction of the TMS-containing epoxy alcohol with lithium TMS-acetylide. Finally, two fragments were joined by the Sonogashira coupling, and the triple bond was reduced to afford RvD1 stereoselectively.
Total synthesis of Resolvin D1, a potent anti-inflammatory lipid mediator
Rodriguez, Ana R.,Spur, Bernd W.
, p. 6990 - 6994 (2013/01/15)
The total synthesis of Resolvin D1, a potent endogenous anti-inflammatory lipid mediator derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C7, C8 and C17 were obtained via a chiral pool strategy from 2-deoxy-d-ribose. Witt
