872998-62-4

Basic information

• Product Name: 2-broMoquinazolin-4-ol
• Synonyms: 2-broMoquinazolin-4-ol;2-Bromo-4(1H)-quinazolinone;2-Bromo-4(3H)-quinazolinone;2-Bromo-3H-quinazolin-4-one
• CAS NO: 872998-62-4
• Molecular Formula: C₈H₅BrN₂O
• Molecular Weight: 225.0421
• Mol File: 872998-62-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 134-136℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-broMoquinazolin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMoquinazolin-4-ol(872998-62-4)
• EPA Substance Registry System: 2-broMoquinazolin-4-ol(872998-62-4)

Safety Data

• Hazardous Substances Data: 872998-62-4(Hazardous Substances Data)

Upstream product

• 13906-09-7 2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 872998-61-3 2,4-dibromoquinazoline 

Downstream Products

• 923018-90-0 3-benzyl-2-bromo-3H-quinazolin-4-one 
• 91634-12-7 C₁₀H₈N₂O 
• 4765-57-5 2-phenethylquinazolin-4-ol 

Relevant articles and documents

Radical reactions with 3H-quinazolin-4-ones: Synthesis of deoxyvasicinone, mackinazolinone, luotonin A, rutaecarpine and tryptanthrin

Alkyl, aryl, heteroaryl and acyl radicals have been cyclised onto the 2-position of 3H-quinazolin-4-one. The side chains containing the radical precursors were attached to the nitrogen atom in the 3-position. The cyclisations take place by aromatic homolytic substitution hence retain the aromaticity of the 3H-quinazolin-4-one ring. The highest yields were obtained using hexamethylditin to facilitate cyclisation rather than reduction without cyclisation. The alkaloids deoxyvasicinone 2, mackinazolinone 3, tryptanthrin 4, luotonin A 5 and rutaecarpine 8 were synthesised by radical cyclisation onto 3H-quinazolin-4-one. This journal is The Royal Society of Chemistry.