873002-63-2Relevant academic research and scientific papers
Synthesis of 5-acyl-6-[2-hydroxy-3-(amino)propylamino]-1,3-dialkyl-1H- pyrimidine-2,4-diones
Singh, Palwinder,Paul, Kamaldeep,Holzer, Wolfgang
, p. 3959 - 3965 (2007/10/03)
A stepwise synthetic approach involving substitution of 6-chloro-1,3-dialkyluracils (5 and 6) with 3-(tert-amino)-2-hydroxypropylamines and subsequent acylation at C5 of uracil has been used to synthesize pyrimidinediones 27-33 in 61-89% overall yield. Th
