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Usage

Uses

Used in Organic Synthesis:
5-bromo-1H-indol-6-amine is used as a building block in organic synthesis for the creation of various molecules with biological activity. Its presence of a bromine atom and amine group allows for versatile chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-bromo-1H-indol-6-amine is utilized as a key intermediate for the synthesis of pharmaceuticals. Its unique structure and functional groups enable the development of new drugs with potential therapeutic effects.
Used in Drug Discovery and Development:
5-bromo-1H-indol-6-amine is studied for its potential anti-cancer, anti-inflammatory, and anti-microbial properties, making it an important compound in drug discovery and development. Its ability to target various biological pathways and exhibit therapeutic effects positions it as a promising candidate for the development of novel pharmaceuticals.
Used in Agrochemicals:
5-bromo-1H-indol-6-amine also has potential applications in the agrochemical industry. Its unique chemical properties and potential biological activity make it a candidate for the development of new agrochemicals, such as pesticides and herbicides, to improve crop protection and yield.

InChI:InChI=1/C8H7BrN2/c9-6-3-5-1-2-11-8(5)4-7(6)10/h1-4,11H,10H2

Upstream product

• 22190-38-1 5-bromo-N-acetylindoline 
• 104447-74-7 5-bromo-6-nitro-1H-indole 

Relevant academic research and scientific papers

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Selective reduction of halogenated nitroarenes with hydrazine hydrate in the presence of Pd/C

A large variety of halogenated nitroarenes have been selectively reduced with hydrazine hydrate in the presence of Pd/C to give the corresponding (halogenated) anilines in good yield.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.