873055-55-1

Basic information

• Product Name: 2,4-di-tert-butyl-5-nitrophenyl methyl carbonate
• Synonyms: 2,4-di-tert-butyl-5-nitrophenyl methyl carbonate;Carbonic acid 2,4-bis(1,1-dimethylethyl)-5-nitrophenyl methyl ester;2,4-Di-tert-butyl-5-nitrophenyl methyl carbonate Carbonic acid 2,4-bis(1,1-dimethylethyl)-5-nitrophenyl methyl ester;,4-di-tert-butyl-5-nitrophenyl methyl carbonate;5-nitro-2,4-di-tert-butylphenyl methyl carbonate;2,4-bis(1,1-dimethylethyl)-5-nitrophenyl methyl ester;2,4-Di-Tert-Butyl-5-Nitrophenyl
• CAS NO: 873055-55-1
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.37
• Mol File: 873055-55-1.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 384℃
• Flash Point: 135℃
• Appearance: /
• Density: 1.110
• CAS DataBase Reference: 2,4-di-tert-butyl-5-nitrophenyl methyl carbonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-di-tert-butyl-5-nitrophenyl methyl carbonate(873055-55-1)
• EPA Substance Registry System: 2,4-di-tert-butyl-5-nitrophenyl methyl carbonate(873055-55-1)

Safety Data

• Hazardous Substances Data: 873055-55-1(Hazardous Substances Data)

Usage

General Description

2,4-Di-tert-butyl-5-nitrophenyl methyl carbonate is a chemical compound typically utilized in the field of chemistry and laboratory research. This chemical, noteworthy for its complex structure, belongs to the organonitrogen compound family characterized by their containing nitrogen atom. It continues to be the subject of intense scientific studies due to its potential applications. However, like many nitro compounds, this substance may pose certain health and environmental risks upon improper handling, demanding utmost care in its use, storage, and disposal. Further details about the compound, including its specific properties or functions, are highly technical and may require a specialized background in chemistry to fully understand.n

InChI:InChI=1S/C16H23NO5/c1-15(2,3)10-8-11(16(4,5)6)13(22-14(18)21-7)9-12(10)17(19)20/h8-9H,1-7H3

Synthetic route

carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester (873055-54-0) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1)

Conditions	Yield
With aluminum (III) chloride; sodium nitrate In dichloromethane at -21 - -12℃; Temperature; Large scale;	83.6%
With sulfuric acid; nitric acid at 0 - 5℃; for 2.5h;	40%
Stage #1: carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester With sulfuric acid In dichloromethane at -5 - 0℃; Stage #2: With nitric acid In dichloromethane at -5 - 0℃; Product distribution / selectivity;

carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester (873055-54-0) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) + carbonic acid 2,4-di(tert-butyl)-6-nitrophenyl ester methyl ester (873055-56-2)

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 50℃; for 2h;
With sulfuric acid; nitric acid at 20 - 50℃; Cooling with ice;
With nitric acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid

carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) + carbonic acid 2,4-di(tert-butyl)-6-nitrophenyl ester methyl ester (873055-56-2)

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 50℃; for 2h;

2,4-di-tert-Butylphenol (96-76-4) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / diethyl ether / 0 - 20 °C 2: nitric acid; sulfuric acid / 1 h / 0 - 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: triethylamine / diethyl ether / 2 h / 0 - 20 °C 2.1: sulfuric acid / dichloromethane / 4.5 h / -5 - 0 °C 2.2: -5 - 5 °C View Scheme
Multi-step reaction with 2 steps 1: triethylamine / diethyl ether / 0 - 20 °C 2: sulfuric acid; nitric acid / 1 h / 0 - 20 °C View Scheme

carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester (873055-54-0) + 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran (96042-30-7) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1)

Conditions	Yield
With sulfuric acid; nitric acid; sodium sulfate In hexane; water
With nitric acid; sodium sulfate

2,4-di-tert-Butylphenol (96-76-4) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) + carbonic acid 2,4-di(tert-butyl)-6-nitrophenyl ester methyl ester (873055-56-2)

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap; triethylamine / dichloromethane / 16 h / 0 - 25 °C 2: sulfuric acid; nitric acid / 2 h / 25 °C / Cooling View Scheme
Multi-step reaction with 2 steps 1: triethylamine / diethyl ether 2: nitric acid / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid View Scheme
Multi-step reaction with 2 steps 1: triethylamine; dmap / dichloromethane / 0 - 20 °C 2: nitric acid; sulfuric acid / 2 h / Cooling with ice View Scheme

2,4-di-tert-Butylphenol (96-76-4) + methyl chloroformate (79-22-1) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1)

Conditions	Yield
Stage #1: 2,4-di-tert-Butylphenol; methyl chloroformate With dmap; triethylamine In dichloromethane at 0 - 5℃; for 2h; Stage #2: With sulfuric acid; nitric acid at 0 - 5℃; for 1.5h;	4.0 g

2,4-di-tert-butyl-5-nitro-phenol (873055-57-3) + methyl chloroformate (79-22-1) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1)

Conditions	Yield
With dmap; triethylamine In dichloromethane at 0 - 30℃;	36.6 g

carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester (873055-54-0) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) + carbonic acid 2,4-di(tert-butyl)-6-nitrophenyl ester methyl ester (873055-56-2) + C12H15NO5

Conditions	Yield
With sulfuric acid; nitric acid at -5 - 0℃; for 4h; Reagent/catalyst; Temperature;

carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester (873055-54-0) → carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) + C12H15NO5

Conditions	Yield
With aluminum (III) chloride; chloro-trimethyl-silane; potassium nitrate In dichloromethane at 20℃; Temperature;

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → 2,4-di-tert-butyl-5-nitro-phenol (873055-57-3)

Conditions	Yield
With sodium hydroxide In methanol; water at 20℃; for 5h;	98%
With potassium hydroxide In methanol
Stage #1: carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester With potassium hydroxide In methanol at 25℃; for 2h; Stage #2: With hydrogenchloride In methanol; water pH=2 - 3;	1.31 g

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) + carbonic acid 2,4-di(tert-butyl)-6-nitrophenyl ester methyl ester (873055-56-2) → 2,4-di-tert-butyl-5-nitro-phenol (873055-57-3) + 2,4-di-tert-butyl-6-nitrophenol (20039-94-5)

Conditions	Yield
With hydrogenchloride; KOH In methanol	A 29% B n/a
Stage #1: carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester; carbonic acid 2,4-di(tert-butyl)-6-nitrophenyl ester methyl ester With potassium hydroxide In methanol at 20℃; for 2h; Stage #2: With hydrogenchloride In methanol; water pH=2 - 3;
Stage #1: carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester; carbonic acid 2,4-di(tert-butyl)-6-nitrophenyl ester methyl ester With methanol; potassium hydroxide at 20℃; for 2h; Stage #2: With hydrogenchloride In water pH=2 - 3;

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → 5-amino-2,4-di-tert-butylphenyl methyl carbonate (1182822-31-6)

Conditions	Yield
With palladium 10% on activated carbon; ammonium formate In ethanol for 2h; Reflux;	29%
With hydrogen; 5% Pd(II)/C(eggshell) In methanol at 25℃; under 1500.15 Torr; Inert atmosphere;
With hydrogen; 5%-palladium/activated carbon In methanol at 20 - 30℃; under 1500.15 Torr; Inert atmosphere;

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → ivacaftor (873054-44-5)

Conditions	Yield
Multi-step reaction with 3 steps 1.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 - 30 °C / 1500.15 Torr / Inert atmosphere 2.1: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 8 h / 47.5 °C 3.1: sodium methylate / 2-methyltetrahydrofuran; methanol / 1 h / 25 °C 3.3: 78 °C View Scheme
Multi-step reaction with 3 steps 1: hydrogen; 5%-palladium/activated carbon / methanol / 25 °C / 1500.15 Torr / Inert atmosphere 2: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 8 h / 47.5 °C 3: sodium methylate / methanol; 2-methyltetrahydrofuran / 1 h View Scheme
Multi-step reaction with 3 steps 1: 5%-palladium/activated carbon; hydrogen / methanol / 25 °C / 1500.15 Torr 2: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 8 h / 47.5 °C 3: sodium methylate; methanol / 2-methyltetrahydrofuran / 1 h View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → 2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate (1246213-45-5)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 20 - 30 °C / 1500.15 Torr / Inert atmosphere 2: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 8 h / 47.5 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogen; 5%-palladium/activated carbon / methanol / 25 °C / 1500.15 Torr / Inert atmosphere 2: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 8 h / 47.5 °C View Scheme
Multi-step reaction with 2 steps 1: 5%-palladium/activated carbon; hydrogen / methanol / 25 °C / 1500.15 Torr 2: pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / 2-methyltetrahydrofuran / 8 h / 47.5 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → 5-amino-2,4-di-tert-butyl-phenol (873055-58-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride; KOH / methanol 2: ammonium formate / ethanol View Scheme
Multi-step reaction with 2 steps 1: potassium hydroxide / methanol 2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 25 - 30 °C View Scheme
Multi-step reaction with 2 steps 1.1: potassium hydroxide / methanol / 2 h / 25 °C 1.2: pH 2 - 3 2.1: ammonium formate; 5%-palladium/activated carbon / ethanol / 2 h / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: methanol; potassium hydroxide / 2 h / 20 °C 1.2: pH 2 - 3 2.1: ammonium formate / 5% palladium over charcoal / ethanol / 2 h / Heating / reflux View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → C27H32N2O5

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → C28H34N2O5

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → C27H32N2O6

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → C26H29FN2O5

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → C30H38N2O5

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → C27H29F3N2O5

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide (1236060-10-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: potassium hydroxide / methanol / 2 h / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxamide

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: potassium hydroxide / methanol / 2 h / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide (1236058-06-2)

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: potassium hydroxide / methanol / 2 h / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide (873051-19-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: potassium hydroxide / methanol / 2 h / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → 6-(tert-butyl)-N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: potassium hydroxide / methanol / 2 h / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (1236058-25-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonium formate; palladium 10% on activated carbon / ethanol / 2 h / Reflux 2: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C 3: potassium hydroxide / methanol / 2 h / 20 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → 2,4-di-tert-butyl-5-(3-(2-fluorophenyl)-3-oxopropanamido)phenyl methyl carbonate

Conditions	Yield
Multi-step reaction with 2 steps 1: iron; ammonium chloride / ethanol / 3 h / Reflux 2: ethyl acetate / 6 h / 25 - 60 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → 2,4-di-tert-butyl-5-(3-ethoxy-2-(2-fluorobenzoyl)acrylamido)phenyl methyl carbonate

Conditions	Yield
Multi-step reaction with 3 steps 1: iron; ammonium chloride / ethanol / 3 h / Reflux 2: pyridine / dichloromethane / 0 - 35 °C 3: triethylamine / toluene / 5 h / 25 - 55 °C View Scheme
Multi-step reaction with 3 steps 1: iron; ammonium chloride / ethanol / 3 h / Reflux 2: ethyl acetate / 6 h / 25 - 60 °C 3: acetic anhydride; zinc(II) chloride / 6 h / 25 - 35 °C View Scheme

carbonic acid 2,4-di(tert-butyl)-5-nitrophenyl ester methyl ester (873055-55-1) → 5-([(E)-3-ethoxyprop-2-enoyl]amino)-2,4-di-tert-butylphenyl methyl carbonate

Conditions	Yield
Multi-step reaction with 2 steps 1: iron; ammonium chloride / ethanol / 3 h / Reflux 2: pyridine / dichloromethane / 0 - 35 °C View Scheme

Upstream product

• 873055-54-0 carbonic acid 2,4-di-tert-butyl-phenyl ester methyl ester 
• 96042-30-7 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 
• 873055-57-3 2,4-di-tert-butyl-5-nitro-phenol 
• 79-22-1 methyl chloroformate 
• 96-76-4 2,4-di-tert-Butylphenol 

Downstream Products

• 873055-57-3 2,4-di-tert-butyl-5-nitro-phenol 
• 20039-94-5 2,4-di-tert-butyl-6-nitrophenol 
• 1182822-31-6 5-amino-2,4-di-tert-butylphenyl methyl carbonate 
• 873055-58-4 5-amino-2-4-di-tert-butyl-phenol 
• 1236058-25-5 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide 
• 873051-19-5 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 1236058-06-2 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 1236060-10-8 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-6-methyl-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 1246213-45-5 2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate 
• 873054-44-5 ivacaftor 

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