873061-48-4

Upstream product

• 3095-95-2 diethylphosphonoacetic acid 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 87750-71-8 diethyl (Ε)-2-(4-nitrophenyl)vinylphosphonate 
• 1436462-90-6 methyl (E)-2-(diethoxyphosphoryl)-3-(4-nitrophenyl)acrylate 
• 912575-61-2 tert-butyl (E)-2-(diethoxyphosphoryl)-3-(4-nitrophenyl)acrylate 

Relevant academic research and scientific papers

Knoevenagel reaction of diethylphosphonoacetic acid: A facile route to diethyl (E)-2-arylvinylphosphonates

Knoevenagel reaction of aromatic aldehydes or α-substituted aliphatic aldehydes with diethylphosphonoacetic acid leads to the formation of 3-substituted-2-(diethoxyphosphoryl)acrylic acids. Decarboxylation of the resulting (E)-3-aryl-2-(diethoxyphosphoryl)acrylic acids afforded diethyl (E)-2-arylvinylphosphonates. Direct synthesis of diethyl vinylphosphonates from some aromatic aldehydes and formaldehyde is also reported. Georg Thieme Verlag Stuttgart.