873065-79-3Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationship studies of N-arylsulfonyl morpholines as γ-secretase inhibitors
Li, Hongmei,Xu, Ruo,Cole, David,Clader, John W.,Greenlee, William J.,Nomeir, Amin A.,Song, Lixin,Zhang, Lili
scheme or table, p. 6606 - 6609 (2010/12/20)
Design and synthesis of cis-2,6-disubstituted N-arylsulfonyl morpholines as novel γ-secretase inhibitors for the potential treatment of Alzheimer's disease (AD) is reported. Several different small alkyl groups are installed on the left-hand side to lower the CYP3A4 liability while maintaining excellent in vitro potency.
SUBSTITUTED N-ARYLSULFONYLHETEROCYCLIC AMINES AS GAMMA-SECRETASE INHIBITORS
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Page/Page column 90, (2010/02/15)
This invention discloses novel gamma secretase inhibitors of the formula I: wherein: L is -O- , -N(R6)-, -S-, -S(O)-, or -S(O2)-; R1 is selected from the group consisting of aryl and heteroaryl; R2 is selected f
