87307-37-7Relevant articles and documents
14β-(2-bromoacetamido)morphine and 14β-(2-bromoacetamido)morphinone
Archer,Seyed-Mozaffari,Osei Gyimah,Bidlack,Abood
, p. 1775 - 1777 (2007/10/02)
14β-(2-Bromoacetamido)morphine (6) and 14β-(2-bromoacetamido)morphinone (9) were prepared preferably from the adduct of thebaine and 1-chloro-1-nitrosocyclohexane, which on reduction in methanol solution gave 14-aminocodeinone (2) and the corresponding ketal (3). When tested in a receptor-binding assay, the IC50 values of 6 and 9 were 15 and 10 nM, respectively. If the incubation time during the assay was increased from 15 to 30 min, irreversible binding of both ligands was observed.