873075-77-5Relevant academic research and scientific papers
COMPOUNDS FOR IMMUNOPOTENTIATION
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Page/Page column 157, (2010/02/15)
Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.
SYNTHESIS OF FLUORO AND AZIDO DERIVATIVES OF PURINE NUCLEOSIDES STARTING FROM NUCLEOSIDE 2',3'-CYCLIC SULFATES
Kobylinskaya, V. I.,Shalamai, A. S.,Gladkaya, V. A.,Makitruk, V. L.,Kondratyuk, I. V.
, p. 712 - 715 (2007/10/02)
The interaction of 5'-O-benzoyl-substituted inosine and N6,5'-O-dibenzoyl-substituted adenosine with sulfuryl chloride has given their 2',3'-cyclic sulfoester derivatives, and these, in a substitution reaction with tetrabutylammonium fluoride and lithium azide, have been converted into 3'-fluoro- and 3'-azido-substituted 3'-deoxynucleosides.The structures of the hypoxanthine and adenine 3'-fluoro-(azido)-3'-deoxyxylofuranosides and also of adenine 2'-fluoro-2'-deoxyarabinofuranoside have shown with the aid of H and 19F NMR spectra.Key words: nucleoside cyclic sulfate; fluoro- and azido-substituted nucleoside; nucleophilic substitution.
