873088-22-3Relevant academic research and scientific papers
Amide forming chemical ligation
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Page/Page column 14-16, (2008/06/13)
An amide is formed by reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amide bond is formed be
Iterative, aqueous synthesis of β3-oligopeptides without coupling reagents
Carrillo, Nancy,Davalos, Eric A.,Russak, Justin A.,Bode, Jeffrey W.
, p. 1452 - 1453 (2007/10/03)
The chemoselective synthesis of amides by decarboxylative couplings of α-ketoacids and isoxazolidines makes possible an iterative approach to poly-β3-peptides. Peptide assembly occurs under aqueous conditions and requires no coupling reagents.
