873090-18-7

Basic information

• Product Name: 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE
• Synonyms: 1,3,4-OXADIAZOL-2(3H)-ONE, 5-(3-BROMOPHENYL)-;5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE;tert-butyl furan-2-ylcarbamate;5-(3-broMophenyl)-2,3-dihydro-1,3,4-oxadiazol-2-one
• CAS NO: 873090-18-7
• Molecular Formula: C₈H₅BrN₂O₂
• Molecular Weight: 241.044
• Mol File: 873090-18-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 185.6-186.3 °C
• Appearance: /
• Density: 1.853 g/cm³
• Refractive Index: 1.699
• PKA: 5.76±0.70(Predicted)
• CAS DataBase Reference: 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE(873090-18-7)
• EPA Substance Registry System: 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE(873090-18-7)

Safety Data

• Hazardous Substances Data: 873090-18-7(Hazardous Substances Data)

Usage

General Description

5-(3-bromo-phenyl)-3H-[1,3,4]oxadiazol-2-one is a chemical compound that belongs to the oxadiazole class of compounds. It is known for its potential biological activities and has been studied for its antimicrobial, antifungal, and anti-inflammatory properties. 5-(3-BROMO-PHENYL)-3H-[1,3,4]OXADIAZOL-2-ONE is characterized by the presence of a 3-bromo-phenyl group and an oxadiazol-2-one ring system, which may contribute to its pharmacological effects. Due to its unique structure and potential therapeutic applications, 5-(3-bromo-phenyl)-3H-[1,3,4]oxadiazol-2-one is of interest to researchers in the fields of medicinal chemistry and drug development.

InChI:InChI=1/C8H5BrN2O2/c9-6-3-1-2-5(4-6)7-10-11-8(12)13-7/h1-4H,(H,11,12)

Upstream product

• 39115-96-3 3-bromo-benzoic acid hydrazide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1422157-64-9 C₁₂H₁₄BrClN₂O₂ 
• 348162-59-4 C₁₂H₁₅BrN₂O₂ 
• 3132-99-8 m-bromobenzoic aldehyde 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 1024613-87-3 1'-[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]-1,4'-bipiperidinyl 
• 1024613-88-4 [5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]-tert-butylamine 
• 1024613-82-8 benzyl[5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl]amine 
• 889117-68-4 C₉H₆N₂O₃ 

Relevant articles and documents

Synthesis of 5-aryl-3H-[1,3,4]oxadiazol-2-ones from N′-(chloro-aryl- methylene)-tert-butylcarbazates using basic alumina as an efficient and recyclable surface under solvent-free condition

The synthesis of biologically important 5-aryl-3H-[1,3,4]oxadiazol-2-ones has been carried out by heating the easily synthesized N′-(chloro-aryl- methylene)-tert-butylcarbazates on basic alumina surface under solvent-free condition. The dual characteristic of basic alumina as a solid support as well as a nucleophile is successfully exploited in these reactions. The method provides special attributions such as reduced reaction times, easier work-up procedures, and good to excellent yields as well as increased purity of products and most importantly environmentally friendly protocols. The basic alumina is easily recovered and utilized for further reactions several times without serious loss of activity.

Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles

We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SnAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,