873091-70-4Relevant academic research and scientific papers
Synthesis, SAR, and Evaluation of 4-[2,4-Difluoro-5-(cyclopropylcarbamoyl)phenylamino]pyrrolo[2,1-f][1,2,4]triazine-based VEGFR-2 kinase inhibitors
Cai, Zhen-wei,Wei, Donna,Borzilleri, Robert M.,Qian, Ligang,Kamath, Amrita,Mortillo, Steven,Wautlet, Barri,Henley, Benjamin J.,Jeyaseelan Sr., Robert,Tokarski, John,Hunt, John T.,Bhide, Rajeev S.,Fargnoli, Joseph,Lombardo, Louis J.
, p. 1354 - 1358 (2008/12/20)
Introduction of the 2,4-difluoro-5-(cyclopropylcarbamoyl)phenylamino group at the C-4 position of the pyrrolo[2,1-f][1,2,4] triazine scaffold led to the discovery of a novel sub-series of inhibitors of VEGFR-2 kinase activity. Subsequent SAR studies on th
Pyrrolotriazine kinase inhibitors
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Page/Page column 17, (2010/02/15)
The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-ca
