87314-56-5 Usage
Uses
Used in Pharmaceutical Industry:
7-ACP is used as a precursor in the synthesis of antimalarial drugs for its potent antimalarial activity. It plays a critical role in the development of medications that target the Plasmodium parasite, which is responsible for causing malaria.
Used in Medicinal Chemistry:
7-ACP is utilized as a valuable intermediate in the synthesis of other pharmaceuticals, contributing to the discovery and development of new drugs with diverse therapeutic applications.
Used in Research and Development:
7-ACP is employed as a research tool in medicinal chemistry, aiding scientists in understanding the structure-activity relationships of potential drug candidates and optimizing their therapeutic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 87314-56-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,3,1 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 87314-56:
(7*8)+(6*7)+(5*3)+(4*1)+(3*4)+(2*5)+(1*6)=145
145 % 10 = 5
So 87314-56-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H17N3O3S/c17-12-14(20)19-13(16(21)22)10(8-23-15(12)19)7-18-6-2-4-9-3-1-5-11(9)18/h2,4,6,12,15H,1,3,5,7-8,17H2/t12-,15-/m1/s1
87314-56-5Relevant academic research and scientific papers
One-pot synthesis of cefpirome sulfate from GCLE
Duan, Xuemin,Lu, Yao,Han, Juan,Chen, Ligong,Zheng, Pengwu
, p. 629 - 636 (2011/04/12)
Cefpirome was synthesized in 37.7% overall yield from 3-chloromethyl-7- phenylacetylamino cephalosporanic acid p-methoxybenzyl ester (GCLE) by sequential substitution of C-3 chloride with iodide and 2,3- cyclopentenopyridine, followed by a one-pot procedure including deprotection of carboxyl group, hydrolysis of 7-phenylacetamido, and reaction with 2-mercaptobenzothiazolyl-(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate (MAEM). The reaction conditions were as follows: obtained from GCLE at low temperature (-5 to 0°C) and absence of light, 3-iodomethyl-7- phenylacetylamino cephalosporanic acid p-methoxybenzyl ester (GILE) without purification was reacted directly with 2,3-cyclopentenopyridine, in which the molar ratio of GCLE, NaI, and 2,3-cyclopentenopyridine was 1:2:4, and the molar ratio of the resulting compound p-methoxybenzyl 7-phenylacetylamido-3-(2,3- cyclopenteno-1-pyridinio)methyl-3-cephem-4-carboxylate iodide and MAEM was 1:1.1. The structure of the intermediate and the target compound obtained were determined by nuclear magnetic resonance spectra and mass spectroscopy.
