873196-22-6Relevant academic research and scientific papers
Synthesis of 1,2-diketones from β-keto nitriles via a protection-oxidative-decyanation-deprotection protocol
Liu, Yu,Yun, Xiliu,Zhang-Negrerie, Daisy,Huang, Jianhui,Du, Yunfei,Zhao, Kang
supporting information; experimental part, p. 2984 - 2994 (2011/11/04)
A variety of 1,2-diketones were prepared from -keto nitriles via a three-step protocol including the protection of the ketones with methoxyamine, oxidative decyanation, and microwave-assisted deprotection in the final step. This approach provides a novel and efficient access to a wide scope of symmetric and unsymmetric 1,2-diketones using molecular oxygen as the oxidant in the decyanation process. Georg Thieme Verlag Stuttgart - New York.
Formation of N-alkoxyindole framework: Intramolecular heterocyclization of 3-alkoxyimino-2-arylalkylnitriles mediated by ferric chloride
Du, Yunfei,Chang, Junbiao,Reiner, John,Zhao, Kang
, p. 2007 - 2010 (2008/09/21)
(Chemical Equation Presented) A variety of functionalized N-alkoxyindole-3-carbonitrile derivatives are achieved under remarkably mild conditions by applying a FeCl3-mediated intramolecular heterocyclization of 3-alkoxyimino-2-arylalkylnitriles. This novel synthesis allows the N-moiety on the side chain to be annulated to the benzene ring as the final synthetic step, which enables the functionalization of the benzenoid portion of the indole at an early stage of the synthesis.
